{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:44:56Z","timestamp":1787496296587,"version":"build-2736575974"},"reference-count":83,"publisher":"Wiley","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Autoimmune Diseases"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>\n                    <jats:italic>Mycobacterium avium<\/jats:italic>\n                    subspecies\n                    <jats:italic>paratuberculosis<\/jats:italic>\n                    (MAP) is the known infectious cause of Johne\u2019s disease, an enteric inflammatory disease mostly studied in ruminant animals. MAP has also been implicated in the very similar Crohn\u2019s disease of humans as well as sarcoidosis. Recently, MAP has been associated with juvenile sarcoidosis (Blau syndrome), autoimmune diabetes, autoimmune thyroiditis, and multiple sclerosis. While it is intuitive to implicate MAP in granulomatous diseases where the microbe participates in the granuloma, it is more difficult to assign a role for MAP in diseases where autoantibodies are a primary feature. MAP may trigger autoimmune antibodies via its heat shock proteins. Mycobacterial heat shock protein 65 (HSP65) is an immunodominant protein that shares sequential and conformational elements with several human host proteins. This molecular mimicry is the proposed etiopathology by which MAP stimulates autoantibodies associated with autoimmune (type 1) diabetes, autoimmune (Hashimoto\u2019s) thyroiditis, and multiple sclerosis. This paper proposes that MAP is a source of mycobacterial HSP65 and acts as a trigger of autoimmune disease.\n                  <\/jats:p>","DOI":"10.1155\/2012\/150824","type":"journal-article","created":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:04:38Z","timestamp":1349049878000},"page":"1-6","source":"Crossref","is-referenced-by-count":19,"title":["<i>M. paratuberculosis<\/i>\n                    Heat Shock Protein 65 and Human Diseases: Bridging Infection and Autoimmunity"],"prefix":"10.1155","volume":"2012","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4301-6101","authenticated-orcid":true,"given":"Coad Thomas","family":"Dow","sequence":"first","affiliation":[{"name":"Chippewa Valley Eye Clinic, Wisconsin and Eye Research Institute, University of Wisconsin-Madison, 2715 Damon Street, Eau Claire, WI 54701, 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