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However, the dosimetry for the labeled alpha particle is challenging because of the heterogeneous antigen expression among cancer cells and the nature of short-range, high-LET alpha radiation. This paper demonstrates that it is inappropriate to investigate the therapeutic efficacy of TAT by macrodosimetry. The objective of this work is to review the microdosimetry of TAT as a function of the cell geometry, source-target configuration, cell sensitivity, and biological factors. A detailed knowledge of each of these parameters is required for accurate microdosimetric calculations.<\/jats:p>","DOI":"10.1155\/2012\/153212","type":"journal-article","created":{"date-parts":[[2012,9,4]],"date-time":"2012-09-04T21:00:41Z","timestamp":1346792441000},"page":"1-6","source":"Crossref","is-referenced-by-count":30,"title":["Microdosimetry for Targeted Alpha Therapy of Cancer"],"prefix":"10.1155","volume":"2012","author":[{"given":"Chen-Yu","family":"Huang","sequence":"first","affiliation":[{"name":"Centre for Experimental Radiation Oncology, St. George Clinical School, University of New South Wales, Kogarah, NSW 2217, Australia"}]},{"given":"Susanna","family":"Guatelli","sequence":"additional","affiliation":[{"name":"Illawarra Cancer Care Centre, Wollongong, NSW 2522, Australia"}]},{"given":"Bradley M.","family":"Oborn","sequence":"additional","affiliation":[{"name":"Illawarra Cancer Care Centre, Wollongong, NSW 2522, Australia"},{"name":"Centre for Medical Radiation 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