{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:31:05Z","timestamp":1790753465502,"version":"4.1.0"},"reference-count":22,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Fondazione Umberto di Mario ONLUS"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Inflammation"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. Immunological factors seem to play a pivotal role in Adult Onset Still's Disease (AOSD). Among all, IL-18 cytokine is overexpressed and drives the inflammatory process.<jats:italic>Objective<\/jats:italic>. We aimed to investigate the levels of IL-18 in sera of Italian patients with AOSD and to assess its possible role as a marker of disease activity.<jats:italic>Methods<\/jats:italic>. IL-18 serum levels were determined by ELISA in 26 Italian patients with AOSD. Disease activity was assessed using Pouchot\u2019s criteria. As controls, 21 patients with Rheumatoid Arthritis (RA), 21 patients with Sjogren's Syndrome (SS), 20 patients with Systemic Lupus Erythematosus (SLE), and 21 healthy subjects (normal human sera, NHS) were evaluated.<jats:italic>Results<\/jats:italic>. IL-18 serum levels were significantly higher in patients with active AOSD than in non-active (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:mrow><\/mml:math>) and control groups (RA<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.0070<\/mml:mn><\/mml:mrow><\/mml:math>, SS<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.0029<\/mml:mn><\/mml:mrow><\/mml:math>, SLE<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.0032<\/mml:mn><\/mml:mrow><\/mml:math>, NHS<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.0004<\/mml:mn><\/mml:mrow><\/mml:math>). A significant correlation between IL-18 serum levels and disease activity (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.0001<\/mml:mn><\/mml:mrow><\/mml:math>), and laboratory parameters as ferritin (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.0127<\/mml:mn><\/mml:mrow><\/mml:math>) and C-reactive protein (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.0032<\/mml:mn><\/mml:mrow><\/mml:math>) was demonstrated.<jats:italic>Conclusions<\/jats:italic>. Higher levels of IL-18 are detected in active AODS patients and correlate with disease activity and inflammatory laboratory features. ROC-AUC analysis of the serum concentration of IL-18 suggests that it can be considered a diagnostic marker of AOSD. This paper supports the targeting of this cytokine as a possible therapeutic option in AOSD.<\/jats:p>","DOI":"10.1155\/2012\/156890","type":"journal-article","created":{"date-parts":[[2012,6,18]],"date-time":"2012-06-18T21:00:58Z","timestamp":1340053258000},"page":"1-6","source":"Crossref","is-referenced-by-count":57,"title":["IL-18 Serum Level in Adult Onset Still\u2019s Disease: A Marker of Disease Activity"],"prefix":"10.1155","volume":"2012","author":[{"given":"Serena","family":"Colafrancesco","sequence":"first","affiliation":[{"name":"Reumatologia, Dipartimento di Medicina Interna e Specialit\u00e0 Mediche, Sapienza Universit\u00e0 di Roma, Viale del Policlinico 155, 00161 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Priori","sequence":"additional","affiliation":[{"name":"Reumatologia, Dipartimento di Medicina Interna e Specialit\u00e0 Mediche, Sapienza Universit\u00e0 di Roma, Viale del Policlinico 155, 00161 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiano","family":"Alessandri","sequence":"additional","affiliation":[{"name":"Reumatologia, Dipartimento di Medicina Interna e Specialit\u00e0 Mediche, Sapienza Universit\u00e0 di Roma, Viale del Policlinico 155, 00161 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Perricone","sequence":"additional","affiliation":[{"name":"Reumatologia, Dipartimento di Medicina Interna e Specialit\u00e0 Mediche, Sapienza Universit\u00e0 di Roma, Viale del Policlinico 155, 00161 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Pendolino","sequence":"additional","affiliation":[{"name":"Reumatologia, Dipartimento di Medicina Interna e Specialit\u00e0 Mediche, Sapienza Universit\u00e0 di Roma, Viale del Policlinico 155, 00161 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Picarelli","sequence":"additional","affiliation":[{"name":"Reumatologia, Dipartimento di Medicina Interna e Specialit\u00e0 Mediche, Sapienza Universit\u00e0 di Roma, Viale del Policlinico 155, 00161 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Valesini","sequence":"additional","affiliation":[{"name":"Reumatologia, Dipartimento di Medicina Interna e Specialit\u00e0 Mediche, Sapienza Universit\u00e0 di Roma, Viale del Policlinico 155, 00161 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1007\/s13317-010-0009-1"},{"issue":"2","key":"2","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1136\/ard.30.2.121","volume":"30","year":"1971","journal-title":"Annals of the Rheumatic 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