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Muscles generate the mechanical strain that contributes to the maintenance of other musculoskeletal tissues, and a vicious circle is established as muscle loss results in bone loss and weakening of tendons. Molecular and proteomic approaches now provide strategies for preventing age-related muscle wasting. Here, attention is paid to the role of the GH\/IGF-1 axis and the special role of the IGFI-Ec (mechano growth factor\/MGF) which is derived from the IGF-I gene by alternative splicing. During aging MGF levels decline but when administered MGF activates the muscle satellite (stem) cells that \u201ckick start\u201d local muscle repair and induces hypertrophy.<\/jats:p>","DOI":"10.1155\/2012\/158279","type":"journal-article","created":{"date-parts":[[2012,3,8]],"date-time":"2012-03-08T21:00:43Z","timestamp":1331240443000},"page":"1-11","source":"Crossref","is-referenced-by-count":43,"title":["Age-Related Loss of Muscle Mass and Strength"],"prefix":"10.1155","volume":"2012","author":[{"given":"Geoffrey","family":"Goldspink","sequence":"first","affiliation":[{"name":"Departments of Surgery, Anatomy and Developmental Biology, University College Medical School, Royal Free Hospital Campus, Hampstead, London NW3 2PF, 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