{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T16:06:05Z","timestamp":1758125165387,"version":"3.37.3"},"reference-count":37,"publisher":"Wiley","license":[{"start":{"date-parts":[[2012,10,13]],"date-time":"2012-10-13T00:00:00Z","timestamp":1350086400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Advances in Bioinformatics"],"published-print":{"date-parts":[[2012,10,13]]},"abstract":"<jats:p><jats:italic>Trypanosoma brucei<\/jats:italic> is a protozoan parasite of major of interest in discovering new genes for drug targets. This parasite alternates its life cycle between the mammal host(s) (bloodstream form) and the insect vector (procyclic form), with two divergent glucose metabolism amenable to <jats:italic>in vitro<\/jats:italic> culture. While the metabolic network of the bloodstream forms has been well characterized, the flux distribution between the different branches of the glucose metabolic network in the procyclic form has not been addressed so far. We present a computational analysis (called Metaboflux) that exploits the metabolic topology of the procyclic form, and allows the incorporation of multipurpose experimental data to increase the biological relevance of the model. The alternatives resulting from the structural complexity of networks are formulated as an optimization problem solved by a metaheuristic where experimental data are modeled in a multiobjective function. \nOur results show that the current metabolic model is in agreement with experimental data and confirms the observed high metabolic flexibility of glucose metabolism. In addition, Metaboflux offers a rational explanation for the high flexibility in the ratio between final products from glucose metabolism, thsat is, flux redistribution through the malic enzyme steps.<\/jats:p>","DOI":"10.1155\/2012\/159423","type":"journal-article","created":{"date-parts":[[2012,10,15]],"date-time":"2012-10-15T07:40:34Z","timestamp":1350286834000},"page":"1-16","source":"Crossref","is-referenced-by-count":10,"title":["Flux Analysis of the <i>Trypanosoma brucei<\/i> Glycolysis Based on a Multiobjective-Criteria Bioinformatic Approach"],"prefix":"10.1155","volume":"2012","author":[{"given":"Amine","family":"Ghozlane","sequence":"first","affiliation":[{"name":"Laboratoire Bordelais de Recherche en Informatique, UMR CNRS 5800, Universit\u00e9 Bordeaux, 351 Cours de la Lib\u00e9ration, 33405 Talence Cedex, France"},{"name":"Centre de Bioinformatique de Bordeaux, Universit\u00e9 Bordeaux Segalen, 142 Rue L\u00e9o Saignat, 33076 Bordeaux Cedex, France"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Bringaud","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9sonance Magn\u00e9tique des Syst\u00e8mes Biologiques, UMR 5536, Universit\u00e9 Bordeaux Segalen, CNRS, 146 rue L\u00e9o Saignat, 33076 Bordeaux, France"}]},{"given":"Hayssam","family":"Soueidan","sequence":"additional","affiliation":[{"name":"The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands"}]},{"given":"Isabelle","family":"Dutour","sequence":"additional","affiliation":[{"name":"Laboratoire Bordelais de Recherche en Informatique, UMR CNRS 5800, Universit\u00e9 Bordeaux, 351 Cours de la Lib\u00e9ration, 33405 Talence Cedex, France"}]},{"given":"Fabien","family":"Jourdan","sequence":"additional","affiliation":[{"name":"Institut National de Recherche en Agronomie, UMR 1331 TOXALIM, 180 Chemin de Tournefeuille, 31027 Toulouse, France"}]},{"given":"Patricia","family":"Th\u00e9bault","sequence":"additional","affiliation":[{"name":"Laboratoire Bordelais de Recherche en Informatique, UMR CNRS 5800, Universit\u00e9 Bordeaux, 351 Cours de la Lib\u00e9ration, 33405 Talence Cedex, France"},{"name":"Centre de Bioinformatique de Bordeaux, Universit\u00e9 Bordeaux Segalen, 142 Rue L\u00e9o Saignat, 33076 Bordeaux Cedex, France"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(77)80476-6"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.030539197"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M407513200"},{"issue":"21","key":"4","doi-asserted-by":"crossref","first-page":"17186","DOI":"10.1074\/jbc.M112.355404","volume":"287","year":"2012","journal-title":"Journal of Biological 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