{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T15:27:26Z","timestamp":1778081246530,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100003008","name":"Ministry of Higher Education, Egypt","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003008","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p><jats:italic>Objectives<\/jats:italic>. This study evaluated IL-17 and IL-11 in gingival crevicular fluid (GCF) of generalized chronic periodontitis (GCP) and generalized aggressive periodontitis (GAgP) patients in relation to periodontopathic bacteria.<jats:italic>Subjects and Methods<\/jats:italic>. GCF samples were collected from 65 subjects including 25 CP, 25 GAgP, and 15 controls (C) and analyzed for IL-17 and IL-11 by an enzyme-linked immunosorbent assay. Molecular detection of bacteria in the dental plaque was determined by polymerase chain reaction.<jats:italic>Results<\/jats:italic>. The total amount of IL-17 was significantly higher in GAgP group than in GCP and C groups<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mo stretchy=\"false\">(<\/mml:mo><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:mrow><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:mrow><\/mml:math>. The IL-11 concentration was significantly higher in C and GCP groups than GAgP group<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mo stretchy=\"false\">(<\/mml:mo><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:mrow><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:mrow><\/mml:math>. The IL-11\/IL-17 ratio was significantly higher in the C group than in GCP and GAgP groups<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mo stretchy=\"false\">(<\/mml:mo><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:mrow><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:mrow><\/mml:math>. Moreover, GAgP group showed lower ratios of IL-11\/IL-17 when compared to GCP group. The high positivity of<jats:italic>P. gingivalis<\/jats:italic>in the dental plaque was associated with significantly increased GCF levels of IL-17 in GCP and GAgP patients.<jats:italic>Conclusions<\/jats:italic>. The increased IL-17 level in GCF of GAgP suggests a potential role in the aetiopathogenesis. Meanwhile, the decreased ratio of IL-11\/IL-17 might reflect an imbalance between the proinflammatory and anti-inflammatory cytokines in different periodontal diseases.<\/jats:p>","DOI":"10.1155\/2012\/174764","type":"journal-article","created":{"date-parts":[[2012,11,26]],"date-time":"2012-11-26T21:07:58Z","timestamp":1353964078000},"page":"1-7","source":"Crossref","is-referenced-by-count":52,"title":["IL-17 and IL-11 GCF Levels in Aggressive and Chronic Periodontitis Patients: Relation to PCR Bacterial Detection"],"prefix":"10.1155","volume":"2012","author":[{"given":"Olfat G.","family":"Shaker","sequence":"first","affiliation":[{"name":"Department of Medical Biochemistry & Molecular Biology, Faculty of Medicine, Cairo University, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noha A.","family":"Ghallab","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Periodontology and Diagnosis, Faculty of Oral and Dental Medicine, Cairo 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