{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:32:05Z","timestamp":1791855125494,"version":"4.3.4"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Thyroid Research"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>Two TRAbs: TSBAb and TSAb. TSBAb causes hypothyroidism. TSAb causes Graves\u2019 hyperthyroidism. TSBAb and TSAb block TSH-binding to cells as TRAb, measured as TSH-binding inhibitory immunoglobulin (TBII). We reevaluate TSBAb and TSAb. We studied TSBAb, TSAb, and TBII over 10 years in 34 TSBAb-positives with hypothyroidism and in 98 TSAb-positives with hyperthyroidism. Half of the 34 TSBAb-positives with hypothyroidism continued to have persistently positive TSBAb, continued to have hypothyroidism, and did not recover from hypothyroidism. Ten of the 98 TSAb-positives with hyperthyroidism continued to have positive TSAb and continued to have hyperthyroidism. TSBAb had disappeared in 15 of the 34 TSBAb-positives with hypothyroidism. With the disappearance of TSBAb, recovery from hypothyroidism was noted in 13 (87%) of the 15 patients. TSAb had disappeared in 73 of the 98 TSAb-positives with hyperthyroidism. With the disappearance of TSAb, remissions of hyperthyroidism were noted in 60 (82%) of the 73. Two of the 34 TSBAb-positives with hypothyroidism developed TSAb-positive Graves\u2019 hyperthyroidism. Two of the 98 TSAb-positive Graves\u2019 patients with hyperthyroidism developed TSBAb-positive hypothyroidism. TSBAb and TSAb are TRAbs. TSBAb-hypothyroidism and TSAb-hyperthyroidism may be two aspects of one disease (TRAb disease). Two forms of autoimmune thyroiditis: atrophic and goitrous. We followed 34 TSBAb-positive patients with hypothyroidism (24 atrophic and 10 goitrous) over 10 years. All of the 10 TSBAb-positive goitrous patients recovered from hypothyroidism and 19 (79%) of the 24 TSBAb-positive atrophic patients continued to have hypothyroidism.<\/jats:p>","DOI":"10.1155\/2012\/182176","type":"journal-article","created":{"date-parts":[[2012,5,10]],"date-time":"2012-05-10T17:02:05Z","timestamp":1336669325000},"page":"1-11","source":"Crossref","is-referenced-by-count":81,"title":["Changes of TSH-Stimulation Blocking Antibody (TSBAb) and Thyroid Stimulating Antibody (TSAb) Over 10 Years in 34 TSBAb-Positive Patients with Hypothyroidism and in 98 TSAb-Positive Graves\u2019 Patients with Hyperthyroidism: Reevaluation of TSBAb and TSAb in TSH-Receptor-Antibody (TRAb)-Positive Patients"],"prefix":"10.1155","volume":"2012","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2163-2758","authenticated-orcid":true,"given":"Nobuyuki","family":"Takasu","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, Aizawa Hospital, 2-5-1 Honjo, Mtasumoto 390-8521, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Matsushita","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Aizawa Hospital, 2-5-1 Honjo, Mtasumoto 390-8521, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"8","key":"1","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1007\/BF03348001","volume":"20","year":"1997","journal-title":"Journal of Endocrinological Investigation"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2004.03991.x"},{"issue":"8","key":"3","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1056\/NEJM199202203260803","volume":"326","year":"1992","journal-title":"The New England Journal of Medicine"},{"issue":"5","key":"4","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1210\/jcem-46-5-734","volume":"46","year":"1978","journal-title":"Journal of Clinical Endocrinology and 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