{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T02:22:11Z","timestamp":1791426131827,"version":"4.3.3"},"reference-count":82,"publisher":"Wiley","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Dentistry"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>Restorative and endodontic procedures have been recently developed in an attempt to preserve the vitality of dental pulp after exposure to external stimuli, such as caries infection or traumatic injury. When damage to dental pulp is reversible, pulp wound healing can proceed, whereas irreversible damage induces pathological changes in dental pulp, eventually requiring its removal. Nonvital teeth lose their defensive abilities and become severely damaged, resulting in extraction. Development of regeneration therapy for the dentin-pulp complex is important to overcome limitations with presently available therapies. Three strategies to regenerate the dentin-pulp complex have been proposed; regeneration of the entire tooth, local regeneration of the dentin-pulp complex from amputated dental pulp, and regeneration of dental pulp from apical dental pulp or periapical tissues. In this paper, we focus on the local regeneration of the dentin-pulp complex by application of exogenous growth factors and scaffolds to amputated dental pulp.<\/jats:p>","DOI":"10.1155\/2012\/190561","type":"journal-article","created":{"date-parts":[[2011,11,17]],"date-time":"2011-11-17T16:01:00Z","timestamp":1321545660000},"page":"1-8","source":"Crossref","is-referenced-by-count":42,"title":["Local Regeneration of Dentin-Pulp Complex Using Controlled Release of FGF-2 and Naturally Derived Sponge-Like Scaffolds"],"prefix":"10.1155","volume":"2012","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1797-6988","authenticated-orcid":true,"given":"Chiaki","family":"Kitamura","sequence":"first","affiliation":[{"name":"Division of Pulp Biology, Operative Dentistry and Endodontics, Department of Cariology and Periodontology, Kyushu Dental College, Manazuru 2-6-1, Kokurakita, Kitakyushu 803-8580, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuji","family":"Nishihara","sequence":"additional","affiliation":[{"name":"Division of Infections and Molecular Biology, Department of Health Promotion, Kyushu Dental College, Manazuru 2-6-1, Kokurakita, Kitakyushu 803-8580, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masamichi","family":"Terashita","sequence":"additional","affiliation":[{"name":"Division of Comprehensive Dentistry, Department of Clinical Communication and Practice, Kyushu Dental College, Manazuru 2-6-1, Kokurakita, Kitakyushu 803-8580, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiko","family":"Tabata","sequence":"additional","affiliation":[{"name":"Department of Biomaterials, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayako","family":"Washio","sequence":"additional","affiliation":[{"name":"Division of Pulp Biology, Operative Dentistry and Endodontics, Department of Cariology and Periodontology, Kyushu Dental College, Manazuru 2-6-1, Kokurakita, Kitakyushu 803-8580, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"6","key":"1","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1177\/00220345010800061001","volume":"80","year":"2001","journal-title":"Journal of Dental Research"},{"issue":"2","key":"2","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1177\/154405910308200203","volume":"82","year":"2003","journal-title":"Journal of Dental Research"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.20340"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.20967"},{"issue":"9","key":"5","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1177\/154405910608500909","volume":"85","year":"2006","journal-title":"Journal of Dental Research"},{"issue":"1","key":"6","first-page":"273","volume":"39","year":"1995","journal-title":"International Journal of Developmental Biology"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1998.4285"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-006-0230-4"},{"issue":"2","key":"9","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1365-2591.1994.tb00234.x","volume":"27","year":"1994","journal-title":"International Endodontic Journal"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2005.10.056"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2007.07.018"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2008.01484.x"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1126\/science.1171643"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.cden.2005.11.005"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1177\/154405910808700811"},{"issue":"7","key":"16","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1177\/154405910408300703","volume":"83","year":"2004","journal-title":"Journal of Dental Research"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1679\/aohc.68.89"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2006.01.055"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(03)00210-2"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.06.004"},{"issue":"5","key":"21","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1089\/ten.teb.2011.0041","volume":"17","year":"2011","journal-title":"Tissue Engineering Part B"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth1012"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2011.01.052"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0902944106"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.8.6.735"},{"issue":"3","key":"26","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1034\/j.1600-0722.2000.108003202.x","volume":"108","year":"2000","journal-title":"European Journal of Oral Sciences"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9969(01)00100-5"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-005-0144-2"},{"issue":"9","key":"29","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1177\/00220345940730090601","volume":"73","year":"1994","journal-title":"Journal of Dental Research"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1089\/104303403764539369"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1089\/1043034042431164"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3301692"},{"issue":"8","key":"33","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1177\/154405910408300802","volume":"83","year":"2004","journal-title":"Journal of Dental Research"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.2174\/156652306778520665"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.2217\/rme.09.5"},{"issue":"3","key":"36","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1747-4477.2005.tb00317.x","volume":"31","year":"2005","journal-title":"Australian Endodontic Journal"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-002-4070-2"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1007\/s10735-005-2684-1"},{"issue":"9","key":"39","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1177\/154405910608500908","volume":"85","year":"2006","journal-title":"Journal of Dental Research"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(99)00121-0"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1089\/10763270050044452"},{"issue":"2","key":"42","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1089\/ten.1999.5.127","volume":"5","year":"1999","journal-title":"Tissue Engineering"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1163\/156856201744461"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2007.07.025"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2009.03.049"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000079"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2007.11.021"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2008.03.001"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2009.01.009"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21572"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-008-3528-9"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.06.037"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2008.03.011"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M800850200"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.3390\/ma3010241"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2009.03.017"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2008.04.009"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2010.0181"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2011.05.030"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.2011.01044.x"},{"issue":"6","key":"61","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1089\/ten.1999.5.545","volume":"5","year":"1999","journal-title":"Tissue Engineering"},{"issue":"1","key":"62","first-page":"196","volume":"60","year":"2002","journal-title":"Journal of Biomedical Materials Research"},{"issue":"1","key":"63","first-page":"142","volume":"68","year":"2004","journal-title":"Journal of Biomedical Materials Research Part A"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.10011"},{"key":"65","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2003.09.054"},{"issue":"1","key":"66","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1046\/j.1365-2796.1997.00170.x","volume":"242","year":"1997","journal-title":"Journal of Internal Medicine"},{"issue":"5","key":"67","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1177\/002215549804600509","volume":"46","year":"1998","journal-title":"Journal of Histochemistry and Cytochemistry"},{"key":"68","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-440X(00)00256-6"},{"key":"69","doi-asserted-by":"publisher","DOI":"10.1016\/0039-6257(90)90027-S"},{"issue":"3","key":"70","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1016\/S0022-3565(25)13122-4","volume":"277","year":"1996","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"issue":"1","key":"71","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0003-9969(73)90019-8","volume":"18","year":"1973","journal-title":"Archives of Oral Biology"},{"issue":"2","key":"72","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1177\/00220345790580022001","volume":"58","year":"1979","journal-title":"Journal of Dental Research"},{"issue":"4","key":"73","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1034\/j.1600-0722.2000.108004311.x","volume":"108","year":"2000","journal-title":"European Journal of Oral Sciences"},{"issue":"3","key":"74","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0003-9969(95)98810-L","volume":"40","year":"1995","journal-title":"Archives of Oral Biology"},{"key":"75","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.31746"},{"key":"76","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2007.05.015"},{"key":"77","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.31497"},{"key":"78","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2009.07.006"},{"key":"79","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.2011.00817.x"},{"key":"80","doi-asserted-by":"publisher","DOI":"10.4012\/dmj.28.11"},{"key":"81","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2006.01.005"},{"issue":"11","key":"82","first-page":"1277","volume":"33","year":"2007","journal-title":"Journal of Endodontics"}],"container-title":["International Journal of Dentistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijd\/2012\/190561.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijd\/2012\/190561.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijd\/2012\/190561.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T01:46:50Z","timestamp":1741916810000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/ijd\/2012\/190561\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":82,"alternative-id":["190561","190561"],"URL":"https:\/\/doi.org\/10.1155\/2012\/190561","relation":{},"ISSN":["1687-8728","1687-8736"],"issn-type":[{"value":"1687-8728","type":"print"},{"value":"1687-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}