{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T00:03:28Z","timestamp":1744157008940},"reference-count":31,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AIDS Research and Treatment"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p><jats:italic>Objectives<\/jats:italic>. This summary evaluates the outcomes of orthotopic liver transplantation (OLT) of HIV-positive patients in Germany.<jats:italic>Methods<\/jats:italic>. Retrospective chart analysis of HIV-positive patients, who had been liver-transplanted in Germany between July 1997 and July 2011.<jats:italic>Results<\/jats:italic>. 38 transplantations were performed in 32 patients at 9 German transplant centres. The reasons for OLT were end-stage liver disease (ESLD) and\/or liver failure due to hepatitis C (HCV) (), hepatitis B (HBV) (), multiple viral infections of the liver () and Budd-Chiari-Syndrome. In July 2011 19\/32 (60%) of the transplanted patients were still alive with a median survival of 61 months (IQR (interquartile range): 41\u201386 months). 6 patients had died in the early post-transplantation period from septicaemia (), primary graft dysfunction (), and intrathoracal hemorrhage (). Later on 7 patients had died from septicaemia (), delayed graft failure (), recurrent HCC (), and renal failure (). Recurrent HBV infection was efficiently prevented in 11\/12 patients; HCV reinfection occurred in all patients and contributed considerably to the overall mortality.<jats:italic>Conclusions<\/jats:italic>. Overall OLT is a feasible approach in HIV-infected patients with acceptable survival rates in Germany. Reinfection with HCV still remains a major clinical challenge in HIV\/HCV coinfection after OLT.<\/jats:p>","DOI":"10.1155\/2012\/197501","type":"journal-article","created":{"date-parts":[[2012,7,30]],"date-time":"2012-07-30T21:00:32Z","timestamp":1343682032000},"page":"1-9","source":"Crossref","is-referenced-by-count":6,"title":["Orthotopic Liver Transplantation in Human-Immunodeficiency-Virus-Positive Patients in Germany"],"prefix":"10.1155","volume":"2012","author":[{"given":"E.","family":"Anadol","sequence":"first","affiliation":[{"name":"Department of Internal Medicine I, University of Bonn, 53105 Bonn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Beckebaum","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Transplantation Medicine, University Hospital Essen, 45122 Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Radecke","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Transplantation Medicine, University Hospital Essen, 45122 Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Paul","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Transplantation Surgery, University Hospital Essen, 45122 Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Zoufaly","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Hamburg, 20251 Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Bickel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Frankfurt University, Hospital Medical Centre, 60590 Frankfurt, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Hitzenbichler","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, University of Regensburg, 93042 Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Ganten","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Heidelberg University, 69125 Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Kittner","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Mainz University, 55122 Mainz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Stoll","sequence":"additional","affiliation":[{"name":"Department of Immunology and Rheumatology, Medical University of Hannover, 30625 Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Berg","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, T\u00fcbingen University Medical School, 72076 T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Manekeller","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Bonn, 53105 Bonn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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