{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:46:40Z","timestamp":1787017600689,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100004622","name":"Dutch Cancer Society","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Cancer Epidemiology"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>\n                    <jats:italic>Objective<\/jats:italic>\n                    . To compare the occurrence of pre-existing and subsequent comorbidity among older cancer patients (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                      <mml:mrow>\n                        <mml:mo>\u2265<\/mml:mo>\n                        <mml:mn>60<\/mml:mn>\n                      <\/mml:mrow>\n                    <\/mml:math>\n                    years) with older non-cancer patients.\n                    <jats:italic>Material and Methods<\/jats:italic>\n                    . Each cancer patient (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                      <mml:mrow>\n                        <mml:mi>n<\/mml:mi>\n                        <mml:mo>=<\/mml:mo>\n                        <mml:mn>3835<\/mml:mn>\n                      <\/mml:mrow>\n                    <\/mml:math>\n                    , mean age 72) was matched with four non-cancer patients in terms of age, sex, and practice. The occurrence of chronic diseases was assessed cross-sectionally (lifetime prevalence at time of diagnosis) and longitudinally (incidence after diagnosis) for all cancer patients and for breast, prostate, and colorectal cancer patients separately. Cancer and non-cancer patients were compared using logistic and Cox regression analysis.\n                    <jats:italic>Results<\/jats:italic>\n                    . The occurrence of the most common pre-existing and incident chronic diseases was largely similar in cancer and non-cancer patients, except for pre-existing COPD (OR 1.21, 95% CI 1.06\u20131.37) and subsequent venous thrombosis in the first two years after cancer diagnosis (HR 4.20, 95% CI 2.74\u20136.44), which were significantly more frequent (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                      <mml:mrow>\n                        <mml:mi>P<\/mml:mi>\n                        <mml:mo>&lt;<\/mml:mo>\n                        <mml:mn>0.01<\/mml:mn>\n                      <\/mml:mrow>\n                    <\/mml:math>\n                    ) among older cancer compared to non-cancer patients.\n                    <jats:italic>Conclusion<\/jats:italic>\n                    . The frequency of multimorbidity in older cancer patients is high. However, apart from COPD and venous thrombosis, the incidence of chronic diseases in older cancer patients is similar compared to non-cancer patients of the same age, sex, and practice.\n                  <\/jats:p>","DOI":"10.1155\/2012\/206414","type":"journal-article","created":{"date-parts":[[2012,8,23]],"date-time":"2012-08-23T17:00:46Z","timestamp":1345741246000},"page":"1-7","source":"Crossref","is-referenced-by-count":35,"title":["Chronic Diseases among Older Cancer Survivors"],"prefix":"10.1155","volume":"2012","author":[{"given":"Laura","family":"Deckx","sequence":"first","affiliation":[{"name":"Department of General Practice, Katholieke Universiteit Leuven, Kapucijnenvoer 33, Bus 7001, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjan","family":"van den Akker","sequence":"additional","affiliation":[{"name":"Department of General Practice, Katholieke Universiteit Leuven, Kapucijnenvoer 33, Bus 7001, 3000 Leuven, Belgium"},{"name":"Department of General Practice, Maastricht University, Peter Debyeplein 1, P.O. Box 616, 6200 MD Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Job","family":"Metsemakers","sequence":"additional","affiliation":[{"name":"Department of General Practice, Maastricht University, Peter Debyeplein 1, P.O. Box 616, 6200 MD Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Knottnerus","sequence":"additional","affiliation":[{"name":"Department of General Practice, Maastricht University, Peter Debyeplein 1, P.O. Box 616, 6200 MD Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Schellevis","sequence":"additional","affiliation":[{"name":"Research Department, NIVEL (Netherlands Institute for Health Services Research), Otterstraat 118\u2013124, P.O. Box 1568, 3500 BN Utrecht, The Netherlands"},{"name":"Department of General Practice, EMGO Institute for Health and Care Research, VU University Medical Centre, Van der Boechorststraat 7, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Buntinx","sequence":"additional","affiliation":[{"name":"Department of General Practice, Katholieke Universiteit Leuven, Kapucijnenvoer 33, Bus 7001, 3000 Leuven, Belgium"},{"name":"Department of General Practice, Maastricht University, Peter Debyeplein 1, P.O. 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