{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T13:31:31Z","timestamp":1780407091698,"version":"3.54.1"},"reference-count":18,"publisher":"Wiley","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Medicine International"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>An outbreak of enzootic ataxia among sheep raised in the northeastern region of Brazil is described. Copper (Cu) deficiency was diagnosed in a herd of 56 sheep, among which five presented characteristic clinical symptoms of enzootic ataxia. The symptoms began 30 days after birth, with a clinical condition that included locomotion difficulty, limb ataxia, tremors, and continual falls. Liver biopsies were performed and blood was collected to determine hepatic and plasmatic Cu, iron (Fe), and zinc (Zn) concentration, respectively. The laboratory results showed that the animals presented low copper concentrations in the plasma and liver, without difference between the clinically healthy animals and those affected by enzootic ataxia. Even after supplementation with adequate Cu levels had been recommended, it was found on a new visit to the farm four months later that one animal still presented a clinical condition and that the hepatic Cu levels of the herd had not risen. Despite the low copper content of the diet, the high hepatic Fe levels found suggest that antagonism due to this element may have been an important factor in triggering copper deficiency in these animals, and thus, additional copper supplementation may be necessary for these animals.<\/jats:p>","DOI":"10.1155\/2012\/207950","type":"journal-article","created":{"date-parts":[[2012,12,18]],"date-time":"2012-12-18T16:00:44Z","timestamp":1355846444000},"page":"1-4","source":"Crossref","is-referenced-by-count":18,"title":["Copper Deficiency in Sheep with High Liver Iron Accumulation"],"prefix":"10.4061","volume":"2012","author":[{"given":"Isadora Karolina Freitas de","family":"Sousa","sequence":"first","affiliation":[{"name":"Departamento de Clinica M\u00e9dica, Faculdade de Medicina Veterin\u00e1ria e Zootecnia, Universidade de S\u00e3o Paulo, Avenida Professor Dr. Orlando Marques de Paiva 87, Cidade Universit\u00e1ria, 05508-270 S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6742-3652","authenticated-orcid":true,"given":"Antonio Humberto","family":"Hamad Minervino","sequence":"additional","affiliation":[{"name":"Departamento de Clinica M\u00e9dica, Faculdade de Medicina Veterin\u00e1ria e Zootecnia, Universidade de S\u00e3o Paulo, Avenida Professor Dr. Orlando Marques de Paiva 87, Cidade Universit\u00e1ria, 05508-270 S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rejane dos Santos","family":"Sousa","sequence":"additional","affiliation":[{"name":"Departamento de Ci\u00eancias Animais, Universidade Federal Rural do Semi\u00e1rido, 59.625-900 Mossor\u00f3, RN, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dowglish Ferreira","family":"Chaves","sequence":"additional","affiliation":[{"name":"Departamento de Ci\u00eancias Animais, Universidade Federal Rural do Semi\u00e1rido, 59.625-900 Mossor\u00f3, RN, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9887-5408","authenticated-orcid":true,"given":"Herbert Sousa","family":"Soares","sequence":"additional","affiliation":[{"name":"Departamento de Ci\u00eancias Animais, Universidade Federal Rural do Semi\u00e1rido, 59.625-900 Mossor\u00f3, RN, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella de Oliveira","family":"Barros","sequence":"additional","affiliation":[{"name":"Departamento de Ci\u00eancias Animais, Universidade Federal Rural do Semi\u00e1rido, 59.625-900 Mossor\u00f3, RN, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina Akiko Sato Cabral de","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Departamento de Clinica M\u00e9dica, Faculdade de Medicina Veterin\u00e1ria e Zootecnia, Universidade de S\u00e3o Paulo, Avenida Professor Dr. Orlando Marques de Paiva 87, Cidade Universit\u00e1ria, 05508-270 S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raimundo Alves Barr\u00eato","family":"J\u00fanior","sequence":"additional","affiliation":[{"name":"Departamento de Ci\u00eancias Animais, Universidade Federal Rural do Semi\u00e1rido, 59.625-900 Mossor\u00f3, RN, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico Lippi","family":"Ortolani","sequence":"additional","affiliation":[{"name":"Departamento de Clinica M\u00e9dica, Faculdade de Medicina Veterin\u00e1ria e Zootecnia, Universidade de S\u00e3o Paulo, Avenida Professor Dr. Orlando Marques de Paiva 87, Cidade Universit\u00e1ria, 05508-270 S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","year":"1999"},{"issue":"6","key":"2","first-page":"289","volume":"45","year":"2003","journal-title":"Veterinary and Human Toxicology"},{"key":"3","year":"2010"},{"key":"4","first-page":"57","volume":"12","year":"1997","journal-title":"International Journal Animal Science"},{"issue":"1","key":"5","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1590\/S0100-736X2003000100005","volume":"23","year":"2003","journal-title":"Pesquisa Veterinaria Brasileira"},{"issue":"1","key":"6","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1079\/BJN19830013","volume":"49","year":"1983","journal-title":"British Journal of Nutrition"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1023\/A:1020702213099"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2006-814"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1590\/S0103-84782006000400025"},{"issue":"3","key":"11","first-page":"677","volume":"5","year":"1983","journal-title":"Veterinary Clinics of North America: Large Animal Practice"},{"issue":"3","key":"12","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1590\/S0103-84782009000300025","volume":"39","year":"2009","journal-title":"Ciencia Rural"},{"issue":"6","key":"13","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1080\/00480169.2008.36856","volume":"56","year":"2008","journal-title":"New Zealand Veterinary Journal"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2009.05.002"},{"key":"16","year":"2002"},{"issue":"2","key":"15","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1590\/S0100-736X1999000200001","volume":"19","year":"1999","journal-title":"Pesquisa Veterinaria Brasileira"},{"key":"17","first-page":"112","volume":"7","year":"2004","journal-title":"Veterinary Science in the Tropics"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-736X2011000500006"},{"issue":"3","key":"19","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0034-5288(18)31865-4","volume":"37","year":"1984","journal-title":"Research in Veterinary Science"}],"container-title":["Veterinary Medicine International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/vmi\/2012\/207950.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/vmi\/2012\/207950.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/vmi\/2012\/207950.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,7]],"date-time":"2019-07-07T01:45:41Z","timestamp":1562463941000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/vmi\/2012\/207950\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":18,"alternative-id":["207950","207950"],"URL":"https:\/\/doi.org\/10.1155\/2012\/207950","relation":{},"ISSN":["2090-8113","2042-0048"],"issn-type":[{"value":"2090-8113","type":"print"},{"value":"2042-0048","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}