{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T11:06:06Z","timestamp":1760267166179},"reference-count":24,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p><jats:italic>Aim<\/jats:italic>. To determine gastric tissue lactoferrin (Lf) levels of<jats:italic>Helicobacter pylori-<\/jats:italic>(Hp-) positive and -negative patients and its effect on anemia.<jats:italic>Methods<\/jats:italic>. Cases in which initial presentation was of abdominal pain and that were Hp-positive at endoscopy were included. Hp-positive cases and -negative controls were divided into two groups.<jats:italic>Results<\/jats:italic>. The study included 64 cases (average: years, 39 male and 25 female). Lf levels were subsequently studied on 61 cases. 45 (73.8%) of these were Hp-positive, while 16 (22.2%) were Hp-negative. In Hp-positive cases, mean staining percentages and density of glands in the antral mucosa were % and , respectively. Hp-negative cases showed significantly different values of % and , respectively. Hemoglobin and serum ferritin values of Hp-positive cases were \/dL and \/mL, but these were comparable with Hp-negative cases (\/dL and \/mL).<jats:italic>Conclusions.<\/jats:italic>Tissue Lf was significantly higher in Hp-positive cases compared to Hp-negative cases, but no difference was observed between the two groups with regards to hemoglobin and ferritin level. As a result, it is difficult to say that this rise in Lf plays a role in the development of iron deficiency anemia in Hp-positive patients.<\/jats:p>","DOI":"10.1155\/2012\/214581","type":"journal-article","created":{"date-parts":[[2012,3,19]],"date-time":"2012-03-19T21:01:27Z","timestamp":1332190887000},"page":"1-5","source":"Crossref","is-referenced-by-count":6,"title":["Lactoferrin Levels in the Gastric Tissue of<i>Helicobacter pylori<\/i>-Positive and -Negative Patients and Its Effect on Anemia"],"prefix":"10.1155","volume":"2012","author":[{"given":"Ya\u015far","family":"Do\u011fan","sequence":"first","affiliation":[{"name":"Division of Pediatric Gastroenterology Hepatology and Nutrition, Department of Pediatrics, Cerrahpa\u015fa Medical Faculty, \u0130stanbul University, \u0130stanbul 23119, Turkey"},{"name":"F\u0131rat \u00dcniversitesi Hastanesi \u00c7ocuk Sa\u011f. ve Hast. Anabilim Dal\u0131 Elaz\u0131\u011f, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T\u00fclay","family":"Erkan","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology Hepatology and Nutrition, Department of Pediatrics, Cerrahpa\u015fa Medical Faculty, \u0130stanbul University, \u0130stanbul 23119, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zerrin","family":"\u00d6nal","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology Hepatology and Nutrition, Department of Pediatrics, Cerrahpa\u015fa Medical Faculty, \u0130stanbul University, \u0130stanbul 23119, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merve","family":"Usta","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology Hepatology and Nutrition, Department of Pediatrics, Cerrahpa\u015fa Medical Faculty, \u0130stanbul University, \u0130stanbul 23119, 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