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Mice were orally administered TSAV (50, 100, and 200\u2009mg\/kg) for five days and then given CCl<jats:sub>4<\/jats:sub>. TSAV pretreatment significantly prevented the CCl<jats:sub>4<\/jats:sub>-induced hepatic damage as indicated by the serum marker enzymes (AST, ALT, and ALP). Parallel to these changes, TSAV also prevented CCl<jats:sub>4<\/jats:sub>-induced oxidative stress by inhibiting lipid peroxidation (MDA) and restoring the levels of antioxidant enzymes (SOD, CAT, GR, and GPX), GSH and GSSG. In addition, TSAV attenuated the serum TNF-<jats:italic>\u03b1<\/jats:italic>and IL-6 levels and inhibited the serum iNOS and NO levels. Liver histopathology indicated that TSAV alleviated CCl<jats:sub>4<\/jats:sub>-induced inflammatory infiltration and focal necrosis. TSAV (200\u2009mg\/kg) also significantly decreased Bak, Bax mRNA and Fas, FasL, p53, and NF-<jats:italic>\u03ba<\/jats:italic>B p65 protein expressions and increased Bcl-2 mRNA and protein expressions. Meanwhile, TSAV significantly downregulated caspase-3 and caspase-8 activities and prevented CCl<jats:sub>4<\/jats:sub>-induced hepatic cell apoptosis. In addition, TSAV exhibited antioxidant activity through scavenging hydroxyl and DPPH free radicals<jats:italic>in vitro<\/jats:italic>. These results indicated that TSAV could protect mice against CCl<jats:sub>4<\/jats:sub>-induced acute liver damage possibly through antioxidant, anti-inflammatory activities and regulating apoptotic-related genes.<\/jats:p>","DOI":"10.1155\/2012\/216061","type":"journal-article","created":{"date-parts":[[2012,11,11]],"date-time":"2012-11-11T01:31:05Z","timestamp":1352597465000},"page":"1-13","source":"Crossref","is-referenced-by-count":20,"title":["Hepatoprotective Activity of the Total Saponins from<i>Actinidia valvata<\/i>Dunn Root against Carbon Tetrachloride-Induced Liver Damage in Mice"],"prefix":"10.1155","volume":"2012","author":[{"given":"Liping","family":"Qu","sequence":"first","affiliation":[{"name":"Department of Traditional Chinese Medicine, Changhai Hospital, Second Military Medical University, 168 Changhai Road, Shanghai 200433, 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