{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T14:25:18Z","timestamp":1694269518076},"reference-count":40,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,6,19]],"date-time":"2012-06-19T00:00:00Z","timestamp":1340064000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Biology International"],"published-print":{"date-parts":[[2012,6,19]]},"abstract":"<jats:p><jats:italic>Aim<\/jats:italic>. To assess IL-1A C[\u2212889]T and IL-1B C[3954]T genotypes as well as haplotypes in relation to sever chronic periodontitis (SCP) among Yemenis. <jats:italic>Materials and Methods<\/jats:italic>. 40 cases with SCP and 40 sex- and age-matched controls were included; all were nonsmokers and free of systemic diseases. Genotyping at each locus was performed using an established PCR-RFLP assay. The Haploview and SimHap software were used to assess data for Hardy-Weinberg's equilibrium (HWE) and linkage disequilibrium (LD) and to obtain subject-level haplotypes. Multiple logistic regression was used to seek for associations in dominant, additive, and recessive models. <jats:italic>Results<\/jats:italic>. Mean plaque index (MPI) showed the strongest association with SCP (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mtext>OR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>16<\/mml:mn><\/mml:mrow><\/mml:math>). A significant LD was observed in the cases (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>D<\/mml:mi><mml:mo>'<\/mml:mo><mml:mo>=<\/mml:mo><mml:mn>0.80<\/mml:mn><\/mml:mrow><\/mml:math> and <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:msup><mml:mi>r<\/mml:mi><mml:mn>2<\/mml:mn><\/mml:msup><mml:mo>=<\/mml:mo><mml:mn>0.47<\/mml:mn><\/mml:mrow><\/mml:math>). The genotype at each locus showed significant association with SCP in the recessive model (TT versus <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mtext>TC<\/mml:mtext><mml:mo>+<\/mml:mo><mml:mtext>CC<\/mml:mtext><\/mml:mrow><\/mml:math>) even after adjustment for MPI (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mtext>OR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>6.29<\/mml:mn><\/mml:mrow><\/mml:math> &amp; 461, resp.). The C-T haplotype conferred protection against SCP in a dominant manner (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mtext>OR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>0.16<\/mml:mn><\/mml:mrow><\/mml:math>). On the other hand, the T-T haplotype in double dose (recessive model) showed strong association with CP (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mtext>OR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>15.6<\/mml:mn><\/mml:mrow><\/mml:math>). <jats:italic>Conclusions<\/jats:italic>. IL-1 two-locus haplotype is associated with SCP in Yemenis. Haplotype-based analysis may be more suited for use in genetic association studies of periodontitis.<\/jats:p>","DOI":"10.1155\/2012\/231309","type":"journal-article","created":{"date-parts":[[2013,10,30]],"date-time":"2013-10-30T15:38:16Z","timestamp":1383147496000},"page":"1-7","source":"Crossref","is-referenced-by-count":6,"title":["Interleukin-1 Two-Locus Haplotype Is Strongly Associated with Severe Chronic Periodontitis among Yemenis"],"prefix":"10.1155","volume":"2012","author":[{"given":"Nezar Noor","family":"Al-hebshi","sequence":"first","affiliation":[{"name":"Molecular Research Laboratory, Faculty of Medical Sciences, University of Science and Technology, Sana'a, Yemen"},{"name":"Faculty of Dentistry, Jazan University, P.O. Box. 114, Jazan, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amat-alrahman Ahmed","family":"Shamsan","sequence":"additional","affiliation":[{"name":"Molecular Research Laboratory, Faculty of Medical Sciences, University of Science and Technology, Sana'a, Yemen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed Sultan","family":"Al-ak'hali","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Faculty of Dentistry, University of Sana\u2019a, Sana'a, Yemen"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2337"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.080213"},{"issue":"1","key":"3","first-page":"3","volume":"7","year":"2005","journal-title":"Journal of the International Academy of 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