{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:15:09Z","timestamp":1760955309960,"version":"3.37.3"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["479335\/2006-0"],"award-info":[{"award-number":["479335\/2006-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Tropical Medicine"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>To compare parasitism and inflammatory process in esophagus and colon from chronic chagasic patients, immunohistochemistry was carried out to research for<jats:italic>T. cruzi<\/jats:italic>and to evaluate the inflammatory infiltrate in the muscular and myenteric plexus in 39 esophagi (20 with and 19 without megaesophagus) and 50 colons (25 with and 25 without megacolon). The frequency of<jats:italic>T. cruzi<\/jats:italic>in megaesophagus was 20%, and in megacolon it was 4%. No amastigotes were found in organs without mega; considering the total of esophagi (with and without mega), the frequency of<jats:italic>T. cruzi<\/jats:italic>would be 10% and 2% in the colon. Myositis and ganglionitis were more frequent and intense in organs with mega compared to those without mega, and in esophagus compared to colon. Qualitatively, inflammatory infiltration in esophagus and colon, with or without mega, was similar, consisting predominantly of T lymphocytes (CD3+), scarce macrophages (CD68+), and rare B lymphocytes (CD20+).<\/jats:p>","DOI":"10.1155\/2012\/232646","type":"journal-article","created":{"date-parts":[[2011,10,30]],"date-time":"2011-10-30T15:00:58Z","timestamp":1319986858000},"page":"1-6","source":"Crossref","is-referenced-by-count":14,"title":["Research on<i>Trypanosoma cruzi<\/i>and Analysis of Inflammatory Infiltrate in Esophagus and Colon from Chronic Chagasic Patients with and without Mega"],"prefix":"10.1155","volume":"2012","author":[{"given":"Eli\u00e2ngela de Castro","family":"C\u00f4bo","sequence":"first","affiliation":[{"name":"Disciplina de Patologia Especial, Universidade Federal do Tri\u00e2ngulo Mineiro (UFTM), Avenida Get\u00falio Guarit\u00e1 130, Abadia 38045-440 Uberaba, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thales Parenti","family":"Silveira","sequence":"additional","affiliation":[{"name":"Disciplina de Patologia Especial, Universidade Federal do Tri\u00e2ngulo Mineiro (UFTM), Avenida Get\u00falio Guarit\u00e1 130, Abadia 38045-440 Uberaba, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adilha Misson","family":"Micheletti","sequence":"additional","affiliation":[{"name":"Disciplina de Patologia Especial, Universidade Federal do Tri\u00e2ngulo Mineiro (UFTM), Avenida Get\u00falio Guarit\u00e1 130, Abadia 38045-440 Uberaba, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Crema","sequence":"additional","affiliation":[{"name":"Disciplina de Cirurgia Digestiva, Universidade Federal do Tri\u00e2ngulo Mineiro (UFTM), Avenida Get\u00falio Guarit\u00e1 130, Abadia 38045-440 Uberaba, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheila Jorge","family":"Adad","sequence":"additional","affiliation":[{"name":"Disciplina de Patologia Especial, Universidade Federal do Tri\u00e2ngulo Mineiro (UFTM), Avenida Get\u00falio Guarit\u00e1 130, Abadia 38045-440 Uberaba, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"4","key":"1","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1590\/S0036-46651987000400002","volume":"29","year":"1987","journal-title":"Revista do Instituto de Medicina Tropical de Sao Paulo"},{"first-page":"312","volume-title":"Cl\u00ednica: manifesta\u00e7\u00f5es digestivas","year":"1979","key":"2"},{"first-page":"1369","volume-title":"Patologia das principais doen\u00e7as tropicais no Brasil. 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