{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T10:32:52Z","timestamp":1773829972317,"version":"3.50.1"},"reference-count":0,"publisher":"Hindawi Limited","issue":"4","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Journal of Gastroenterology"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>BACKGROUND: Patient satisfaction is increasingly regarded as an important aspect of measuring treatment success in individuals with gastroesophageal reflux disease (GERD).<\/jats:p><jats:p>OBJECTIVE: To review how satisfied patients with GERD are with their medication, and to analyze the usefulness of patient satisfaction as a clinical end point by comparing it with symptom improvement.<\/jats:p><jats:p>METHODS: Systematic searches of the PubMed and EMBASE databases identified clinical trials and patient surveys published between 1966 and 2009.<\/jats:p><jats:p>RESULTS: Twelve trials reported that 56% to 100% of patients were \u2018satisfied\u2019 or \u2018very satisfied\u2019 with proton pump inhibitor (PPI) treatment for GERD. Patient satisfaction levels were higher for PPIs than other GERD medications in two trials. The sample-size-weighted average proportion of patients \u2018satisfied\u2019 with their PPI after four weeks of treatment in trials was 93% (95% CI 87% to 99%), with 73% (95% CI 62% to 83%) being \u2018very satisfied\u2019. In four surveys, the average proportion of patients \u2018satisfied\u2019 with their PPI treatment was 82% (95% CI 73% to 90%) and 62% (95% CI 48% to 75%) were \u2018very satisfied\u2019. Seven trials found a positive association between patient satisfaction and symptom improvement, and two surveys between satisfaction and improved health-related quality of life. Three trials found that continuous treatment yielded higher rates of satisfaction than on-demand therapy.<\/jats:p><jats:p>CONCLUSIONS: More than one-half of patients were satisfied with their PPI medication in trials, and more patients were satisfied with PPIs than other medication types. An association between patient satisfaction and symptom resolution was found, suggesting that patient satisfaction is a useful end point for evaluating GERD treatment success.<\/jats:p>","DOI":"10.1155\/2012\/235476","type":"journal-article","created":{"date-parts":[[2016,3,15]],"date-time":"2016-03-15T07:51:44Z","timestamp":1458028304000},"page":"196-204","source":"Crossref","is-referenced-by-count":18,"title":["Patient Satisfaction with Medication for Gastroesophageal Reflux Disease: A Systematic Review"],"prefix":"10.1155","volume":"26","author":[{"given":"Sander Veldhuyzen","family":"van Zanten","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, University of Alberta, Edmonton, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Henderson","sequence":"additional","affiliation":[{"name":"Research Evaluation Unit, Oxford PharmaGenesis Ltd, Oxford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nesta","family":"Hughes","sequence":"additional","affiliation":[{"name":"Research Evaluation Unit, Oxford PharmaGenesis Ltd, Oxford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","container-title":["Canadian Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2012\/235476.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2012\/235476.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,8,23]],"date-time":"2016-08-23T07:14:00Z","timestamp":1471936440000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/cjgh\/2012\/235476\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012]]}},"alternative-id":["235476"],"URL":"https:\/\/doi.org\/10.1155\/2012\/235476","relation":{},"ISSN":["0835-7900"],"issn-type":[{"value":"0835-7900","type":"print"}],"subject":[],"published":{"date-parts":[[2012]]}}}