{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:02:10Z","timestamp":1791180130052,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100003359","name":"Generalitat Valenciana","doi-asserted-by":"publisher","award":["GV2007\/287"],"award-info":[{"award-number":["GV2007\/287"]}],"id":[{"id":"10.13039\/501100003359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>Idiopathic Pulmonary arterial hypertension (IPAH) is characterized by the obstructive remodelling of pulmonary arteries, and a progressive elevation in pulmonary arterial pressure (PAP) with subsequent right-sided heart failure and dead. Hypoxia induces the expression of peroxisome proliferator activated receptor<jats:italic>\u03b3<\/jats:italic>coactivator-1<jats:italic>\u03b1<\/jats:italic>(PGC-1<jats:italic>\u03b1<\/jats:italic>) which regulates oxidative metabolism and mitochondrial biogenesis. We have analysed the expression of PGC-1<jats:italic>\u03b1<\/jats:italic>, cytochrome C (CYTC), superoxide dismutase (SOD), the total antioxidant status (TAS) and the activity of glutathione peroxidase (GPX) in blood samples of IPAH patients. Expression of PGC-1<jats:italic>\u03b1<\/jats:italic>was detected in IPAH patients but not in healthy volunteers. The mRNA levels of SOD were lower in IPAH patients compared to controls (3.93 \u00b1 0.89 fold change). TAS and GPX activity were lower too in patients compared to healthy donors, (0.13 \u00b1 0.027 versus 0.484 \u00b1 0.048\u2009mM and 56.034 \u00b1 10.37 versus 165.46 \u00b1 11.38\u2009nmol\/min\/mL, resp.). We found a negative correlation between expression levels of PGC-1<jats:italic>\u03b1<\/jats:italic>and age, PAP and PVR, as well as a positive correlation with CI, PaO<jats:sub>2<\/jats:sub>, mRNA levels of CYTC and SOD, TAS and GPX activity. These results taken together are indicative of the possible role of PGC-1<jats:italic>\u03b1<\/jats:italic>as a potential biomarker of the progression of IPAH.<\/jats:p>","DOI":"10.1155\/2012\/236572","type":"journal-article","created":{"date-parts":[[2012,8,29]],"date-time":"2012-08-29T17:01:08Z","timestamp":1346259668000},"page":"1-8","source":"Crossref","is-referenced-by-count":29,"title":["PGC-1<i>\u03b1<\/i>Induction in Pulmonary Arterial Hypertension"],"prefix":"10.1155","volume":"2012","author":[{"given":"Manuel","family":"Mata","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine, Research Foundation of the University General Hospital of Valencia, 46014 Valencia, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red (CIBER) de Enfermedades Respiratorias, 46014 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Sarrion","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Research Foundation of the University General Hospital of Valencia, 46014 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Milian","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Valencia, 46010 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Juan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Valencia, 46010 Valencia, Spain"},{"name":"Division of Pneumology, University General Hospital of Valencia, 46014 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Ramon","sequence":"additional","affiliation":[{"name":"Division of Pneumology, University General Hospital of Valencia, 46014 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dolores","family":"Naufal","sequence":"additional","affiliation":[{"name":"Division of Pneumology, University General Hospital of La F\u00e9, 46026 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Gil","sequence":"additional","affiliation":[{"name":"Division of Pneumology, University General Hospital of Alicante, 03010 Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Ridocci","sequence":"additional","affiliation":[{"name":"Division of Pneumology, University General Hospital of Valencia, 46014 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Fabregat-Andr\u00e9s","sequence":"additional","affiliation":[{"name":"Division of Pneumology, University General Hospital of Valencia, 46014 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Cortijo","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Research Foundation of the University General Hospital of Valencia, 46014 Valencia, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red (CIBER) de Enfermedades Respiratorias, 46014 Valencia, Spain"},{"name":"Department of Pharmacology, University of Valencia, 46010 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"2","key":"1","doi-asserted-by":"crossref","first-page":"216","DOI":"10.7326\/0003-4819-107-2-216","volume":"107","year":"1987","journal-title":"Annals of Internal Medicine"},{"issue":"16","key":"2","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.1161\/CIRCULATIONAHA.109.192230","volume":"119","year":"2009","journal-title":"Circulation"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00139009"},{"issue":"5","key":"4","doi-asserted-by":"crossref","first-page":"343","DOI":"10.7326\/0003-4819-115-5-343","volume":"115","year":"1991","journal-title":"Annals of Internal 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