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In the search for hepatoprotective therapeutic agents,<jats:italic>Graptopetalum paraguayense<\/jats:italic>(GP) showed greater cytotoxicity toward hepatic stellate cells than other tested herbal medicines. Histopathological and biochemical analyses suggest that GP treatment significantly prevented DMN-induced hepatic inflammation and fibrosis in rats. Microarray profiling indicated that expression of most of metabolism- and cell growth and\/or maintenance-related genes recovered to near normal levels following GP treatment as classified by gene ontology and LSM analysis, was observed. ANOVA showed that expression of 64% of 256 liver damage-related genes recovered significantly after GP treatment. By examining rat liver samples with Q-RT-PCR, five liver damage-related genes were identified. Among them,<jats:italic>Egr1<\/jats:italic>and<jats:italic>Nrg1<\/jats:italic>may serve as necroinflammatory markers, and<jats:italic>Btg2<\/jats:italic>may serve as a fibrosis marker.<jats:italic>Oldr1<\/jats:italic>and<jats:italic>Hmgcs1<\/jats:italic>were up- and down-regulated markers, respectively. A publicly accessible website has been established to provide access to these data Identification of 44 necroinflammation-related and 62 fibrosis-related genes provides useful insight into the molecular mechanisms underlying liver damage and provides potential targets for the rational development of therapeutic drugs such as GP.<\/jats:p>","DOI":"10.1155\/2012\/256561","type":"journal-article","created":{"date-parts":[[2012,7,3]],"date-time":"2012-07-03T17:01:43Z","timestamp":1341334903000},"page":"1-15","source":"Crossref","is-referenced-by-count":7,"title":["Evaluation of the Chinese Medicinal Herb,<i>Graptopetalum paraguayense<\/i>, as a Therapeutic Treatment for Liver Damage in Rat Models"],"prefix":"10.1155","volume":"2012","author":[{"given":"Li-Jen","family":"Su","sequence":"first","affiliation":[{"name":"Institute of Systems Biology and Bioinformatics, National Central University, Jhongli City 32001, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Hsueh","family":"Yang","sequence":"additional","affiliation":[{"name":"Graduate Institute of Microbiology and Public Health, National Chung Hsing University, Taichung 40227, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiu-Feng","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli County, Zhunan 35053, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Ling","family":"Yuo","sequence":"additional","affiliation":[{"name":"Division of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli County, Zhunan 35053, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Chu","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Biomarker Technology Development Division, Biomedical Technology and Device Research Labs, 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