{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T21:15:55Z","timestamp":1754601355262,"version":"3.37.3"},"reference-count":54,"publisher":"Wiley","license":[{"start":{"date-parts":[[2012,12,19]],"date-time":"2012-12-19T00:00:00Z","timestamp":1355875200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Allergy"],"published-print":{"date-parts":[[2012,12,19]]},"abstract":"<jats:p>Circulating angiotensin-II protects the circulation against sudden falls in blood pressure and is generated by the enzymatic action of angiotensin converting enzyme (ACE) on angiotensin-I. The ACE genes have 2 allelic forms, \u201cI\u201d and \u201cD.\u201d The \u201cD\u201d genotype has both highest angiotensin-II generation and serum ACE levels compared to \u201cI\u201d. \n120 patients with IgE-anaphylaxis, 119 healthy controls, and 49 atopics had serum ACE levels, ACE genotype, and renin levels determined. \n Plasma renin levels were identical for all groups. \nSerum ACE levels and genotypes were similar for healthy controls (HC) and atopics, but lower in anaphylaxis (), with ACE genotypes also showing increased \u201cI\u201d genes (). This effect was more pronounced in subjects manifesting airway angioedema and cardiovascular collapse (AACVS) than mild cutaneous and respiratory (CRA) symptoms. AACVS was significantly associated with the presence of \u201cI\u201d genes. For \u201cID\u201d genotype OR is 5.6, 95% CI 1.8 to 17.4, and for \u201cII\u201d genotype OR is 44, 95% CI 5 to 1891 within the anaphylaxis group = 0.001. \n The results show a difference in the genotype frequency between control and anaphylaxis, suggesting a role for the renin angiotensin system in anaphylaxis manifesting with airway angioedema and cardiovascular collapse.<\/jats:p>","DOI":"10.1155\/2012\/258145","type":"journal-article","created":{"date-parts":[[2012,12,19]],"date-time":"2012-12-19T13:40:22Z","timestamp":1355924422000},"page":"1-9","source":"Crossref","is-referenced-by-count":6,"title":["IgE-Mediated Anaphylaxis to Foods, Venom, and Drugs: Influence of Serum Angiotensin Converting Enzyme Levels and Genotype"],"prefix":"10.1155","volume":"2012","author":[{"given":"V. 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