{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T00:11:00Z","timestamp":1649203860647},"reference-count":9,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Pediatrics"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>Screening for coeliac disease is recommended for children from certain risk groups, with implications for diagnostic procedures and dietetic management. The risk of a malignant complication in untreated coeliac disease is not considered high in children. We present the case of a girl with type I diabetes who developed weight loss, fatigue, and inguinal lymphadenopathy. Four years before, when she was asymptomatic, a screening coeliac tTG test was positive, but gluten was not eliminated from her diet. Based on clinical examination, a duodenal biopsy, and an inguinal lymph node biopsy were performed, which confirmed both coeliac disease and an anaplastic large-cell lymphoma. HLA-typing demonstrated that she was homozygous for HLA-DQ8, which is associated with higher risk for celiac disease, more severe gluten sensitivity, and diabetes susceptibility. She responded well to chemotherapy and has been in remission for over 4 years. She remains on a gluten-free diet. This is the first case reporting the association of coeliac disease, type I diabetes, and anaplastic large-cell lymphoma in childhood. The case highlights the malignancy risk in a genetically predisposed individual, and the possible role of a perpetuated immunologic response by prolonged gluten exposure.<\/jats:p>","DOI":"10.1155\/2012\/269689","type":"journal-article","created":{"date-parts":[[2012,10,4]],"date-time":"2012-10-04T17:04:48Z","timestamp":1349370288000},"page":"1-3","source":"Crossref","is-referenced-by-count":0,"title":["Anaplastic Large-Cell Lymphoma in a Child with Type I Diabetes and Unrecognised Coeliac Disease"],"prefix":"10.1155","volume":"2012","author":[{"given":"Jemima","family":"Sharp","sequence":"first","affiliation":[{"name":"Department of Paediatric Gastroenterology, Alder Hey Children\u2019s NHS Foundation Trust, Eaton Road, Liverpool L12 2AP, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barry","family":"Pizer","sequence":"additional","affiliation":[{"name":"Department of Paediatric Oncology, Alder Hey Children\u2019s NHS Foundation Trust, Eaton Road, Liverpool L12 2AP, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Kokai","sequence":"additional","affiliation":[{"name":"Department of Paediatric Pathology, Alder Hey Children's NHS Foundation Trust, Eaton Road, Liverpool L12 2AP, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus K. H.","family":"Auth","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology, Alder Hey Children\u2019s NHS Foundation Trust, Eaton Road, Liverpool L12 2AP, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.032094"},{"issue":"3","key":"2","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1097\/00005176-199310000-00021","volume":"17","year":"1993","journal-title":"Journal of Pediatric Gastroenterology and Nutrition"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200107000-00020"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1136\/adc.87.6.495"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-10-119974"},{"issue":"3","key":"6","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1136\/gut.30.3.333","volume":"30","year":"1989","journal-title":"Gut"},{"issue":"5","key":"7","doi-asserted-by":"crossref","first-page":"248","DOI":"10.4321\/S1130-01082012000500005","volume":"104","year":"2012","journal-title":"Revista Espa\u00f1ola de Enfermedades Digestivas"},{"key":"8","volume":"38, article 10","year":"2012","journal-title":"Italian Journal of Pediatrics"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1080\/00365520802116422"}],"container-title":["Case Reports in Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cripe\/2012\/269689.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cripe\/2012\/269689.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cripe\/2012\/269689.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,20]],"date-time":"2017-06-20T21:01:16Z","timestamp":1497992476000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/cripe\/2012\/269689\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":9,"alternative-id":["269689","269689"],"URL":"https:\/\/doi.org\/10.1155\/2012\/269689","relation":{},"ISSN":["2090-6803","2090-6811"],"issn-type":[{"value":"2090-6803","type":"print"},{"value":"2090-6811","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}