{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:00:08Z","timestamp":1792033208261,"version":"4.4.0"},"reference-count":69,"publisher":"Wiley","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG021904"],"award-info":[{"award-number":["AG021904"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG031782"],"award-info":[{"award-number":["AG031782"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK041918"],"award-info":[{"award-number":["DK041918"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS038370"],"award-info":[{"award-number":["NS038370"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK087776"],"award-info":[{"award-number":["DK087776"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG021904"],"award-info":[{"award-number":["AG021904"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG031782"],"award-info":[{"award-number":["AG031782"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK041918"],"award-info":[{"award-number":["DK041918"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS038370"],"award-info":[{"award-number":["NS038370"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK087776"],"award-info":[{"award-number":["DK087776"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG021904"],"award-info":[{"award-number":["AG021904"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG031782"],"award-info":[{"award-number":["AG031782"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK041918"],"award-info":[{"award-number":["DK041918"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS038370"],"award-info":[{"award-number":["NS038370"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK087776"],"award-info":[{"award-number":["DK087776"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG021904"],"award-info":[{"award-number":["AG021904"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG031782"],"award-info":[{"award-number":["AG031782"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK041918"],"award-info":[{"award-number":["DK041918"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS038370"],"award-info":[{"award-number":["NS038370"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK087776"],"award-info":[{"award-number":["DK087776"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG021904"],"award-info":[{"award-number":["AG021904"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG031782"],"award-info":[{"award-number":["AG031782"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK041918"],"award-info":[{"award-number":["DK041918"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS038370"],"award-info":[{"award-number":["NS038370"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK087776"],"award-info":[{"award-number":["DK087776"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Cell Biology"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>Lipid droplets (LDs), initially considered \u201cinert\u201d lipid deposits, have gained during the last decade the classification of cytosolic organelles due to their defined composition and the multiplicity of specific cellular functions in which they are involved. The classification of LD as organelles brings along the need for their regulated turnover and recent findings support the direct contribution of autophagy to this turnover through a process now described as lipophagy. This paper focuses on the characteristics of this new type of selective autophagy and the cellular consequences of the mobilization of intracellular lipids through this process. Lipophagy impacts the cellular energetic balance directly, through lipid breakdown and, indirectly, by regulating food intake. Defective lipophagy has been already linked to important metabolic disorders such as fatty liver, obesity and atherosclerosis, and the age-dependent decrease in autophagy could underline the basis for the metabolic syndrome of aging.<\/jats:p>","DOI":"10.1155\/2012\/282041","type":"journal-article","created":{"date-parts":[[2012,3,29]],"date-time":"2012-03-29T10:30:04Z","timestamp":1333017004000},"page":"1-12","source":"Crossref","is-referenced-by-count":425,"title":["Lipophagy: Connecting Autophagy and Lipid Metabolism"],"prefix":"10.1155","volume":"2012","author":[{"given":"Rajat","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA"},{"name":"Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA"},{"name":"Diabetes Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Maria","family":"Cuervo","sequence":"additional","affiliation":[{"name":"Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA"},{"name":"Diabetes Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA"},{"name":"Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA"},{"name":"Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY 10461, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E03-09-0704"},{"issue":"5","key":"2","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.cmet.2011.04.004","volume":"13","year":"2011","journal-title":"Cell Metabolism"},{"issue":"2","key":"3","doi-asserted-by":"crossref","first-page":"C11","DOI":"10.1083\/jcb.35.2.C11","volume":"35","year":"1967","journal-title":"Journal of Cell Biology"},{"issue":"5","key":"4","first-page":"1289","volume":"43","year":"1984","journal-title":"Federation Proceedings"},{"issue":"1","key":"5","first-page":"49","volume":"5","year":"1985","journal-title":"Diabetes\/Metabolism Reviews"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(94)00672-5"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(93)80398-E"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1172\/JCI46069"},{"issue":"3","key":"9","volume":"3","year":"2011","journal-title":"Cold Spring Harbor Perspectives in Biology"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2008.10.002"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2008.07.004"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M108414200"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E05-07-0659"},{"issue":"1","key":"14","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1247\/csf.8.35","volume":"8","year":"1983","journal-title":"Cell Structure and Function"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.4161\/rna.8.2.15011"},{"issue":"4","key":"16","first-page":"2096","volume":"86","year":"2011","journal-title":"Journal of Virology"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2010.10.004"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2009.11.014"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1038\/nature06639"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1038\/nature07976"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-4027"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2009.04.026"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0810611105"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900441"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3028"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.4161\/auto.7.3.14487"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M207712200"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M706841200"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M413312200"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.190785"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-008-0449-0"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200803137"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.04.009"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1000576"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.06.008"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2528"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.03.023"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1126\/science.1124147"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200524301"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2010.05799.x"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1038\/nature07181"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1038\/nn1456"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1038\/nature03029"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1126\/science.1196371"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1038\/nm1392"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.254417"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.2337\/db11-0120"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1172\/JCI39228"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0906048106"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.03.039"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.4161\/auto.6.6.12574"},{"issue":"4","key":"52","doi-asserted-by":"crossref","first-page":"173","DOI":"10.14712\/fb2010056040173","volume":"56","year":"2010","journal-title":"Folia Biologica"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.09.101"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2010.07.009"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-009-0926-3"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2010.117"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1096\/fj.09-144519"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.111.184341"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.07.041"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.07.010"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2010.10.006"},{"key":"62","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-1681"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2010.00023"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.210245"},{"key":"65","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2008.10.002"},{"key":"66","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.12.023"},{"key":"67","doi-asserted-by":"publisher","DOI":"10.1089\/rej.2008.0806"},{"key":"68","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2011.07.042"},{"issue":"8","key":"69","doi-asserted-by":"crossref","first-page":"332","DOI":"10.12968\/bjcn.2009.14.8.43512","volume":"14","year":"2009","journal-title":"British Journal of Community Nursing"}],"container-title":["International Journal of Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijcb\/2012\/282041.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijcb\/2012\/282041.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijcb\/2012\/282041.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T09:29:33Z","timestamp":1742808573000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/ijcb\/2012\/282041\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":69,"alternative-id":["282041","282041"],"URL":"https:\/\/doi.org\/10.1155\/2012\/282041","relation":{},"ISSN":["1687-8876","1687-8884"],"issn-type":[{"value":"1687-8876","type":"print"},{"value":"1687-8884","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}