{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T15:10:18Z","timestamp":1788361818860,"version":"build-2803163510"},"reference-count":103,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,12,20]],"date-time":"2012-12-20T00:00:00Z","timestamp":1355961600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemotherapy Research and Practice"],"published-print":{"date-parts":[[2012,12,20]]},"abstract":"<jats:p>Chemotherapy has been used for cancer treatment already for almost 70 years by targeting the proliferation potential and metastasising ability of tumour cells. Despite the progress made in the development of potent chemotherapy drugs, their toxicity to normal tissues and adverse side effects in multiple organ systems as well as drug resistance have remained the major obstacles for the successful clinical use. Cytotoxic agents decrease considerably the quality of life of cancer patients manifesting as acute complaints and impacting the life of survivors also for years after the treatment. Toxicity often limits the usefulness of anticancer agents being also the reason why many patients discontinue the treatment. The nutritional approach may be the means of helping to raise cancer therapy to a new level of success as supplementing or supporting the body with natural phytochemicals cannot only reduce adverse side effects but improve also the effectiveness of chemotherapeutics. Various plant-derived compounds improve the efficiency of cytotoxic agents, decrease their resistance, lower and alleviate toxic side effects, reduce the risk of tumour lysis syndrome, and detoxify the body of chemotherapeutics. The personalised approach using various phytochemicals provides thus a new dimension to the standard cancer therapy for improving its outcome in a complex and complementary way.<\/jats:p>","DOI":"10.1155\/2012\/282570","type":"journal-article","created":{"date-parts":[[2012,12,20]],"date-time":"2012-12-20T21:03:46Z","timestamp":1356037426000},"page":"1-11","source":"Crossref","is-referenced-by-count":143,"title":["Chemotherapy and Dietary Phytochemical Agents"],"prefix":"10.1155","volume":"2012","author":[{"given":"Katrin","family":"Sak","sequence":"first","affiliation":[{"name":"NGO Praeventio, N\u00e4ituse 22-3, 50407 Tartu, Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/S1028-4559(09)60296-5"},{"key":"2","year":"2002"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2006.01.045"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2009.09.004"},{"key":"5","year":"2009","journal-title":"Philica"},{"issue":"7","key":"6","first-page":"2421","volume":"29","year":"2009","journal-title":"Anticancer Research"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2867-7-9"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2005.11.036"},{"issue":"5","key":"9","first-page":"304","volume":"4","year":"1999","journal-title":"Alternative Medicine Review"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2005.05.036"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2006.04.032"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2009.05.044"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-06-0002"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.2174\/1389450023347371"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2007.06.025"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0800835105"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-89615-9_14"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.11788"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1038\/nature03098"},{"issue":"1","key":"20","doi-asserted-by":"crossref","first-page":"46","DOI":"10.18433\/J3RC77","volume":"12","year":"2009","journal-title":"Journal of Pharmacy and Pharmaceutical Sciences"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2005.07.023"},{"issue":"3","key":"22","first-page":"187","volume":"3","year":"1998","journal-title":"Alternative Medicine Review"},{"key":"23","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1021\/mp200261n","volume":"8","year":"2011","journal-title":"Molecular Pharmaceutics"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2011.08.053"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2008-0162"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2006.10.020"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1038\/ncponc1066"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-06-0067"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.2174\/1874609810902030174"},{"issue":"1","key":"30","doi-asserted-by":"crossref","first-page":"15","DOI":"10.32725\/jab.2009.002","volume":"7","year":"2009","journal-title":"Journal of Applied Biomedicine"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.08.045"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0409897102"},{"issue":"5","key":"33","first-page":"467","volume":"8","year":"2009","journal-title":"Tropical Journal of Pharmaceutical Research"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2004.09.021"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2747"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1101\/sqb.2007.72.030"},{"issue":"7","key":"37","doi-asserted-by":"crossref","first-page":"901","DOI":"10.4161\/cc.4.7.1792","volume":"4","year":"2005","journal-title":"Cell Cycle"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1186\/bcr2148"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2007.03.038"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2073"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1186\/jbiol69"},{"issue":"3","key":"42","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/BF02893390","volume":"11","year":"2005","journal-title":"Pathology and Oncology Research"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23689"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00625-6"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2006.08.046"},{"issue":"3","key":"46","first-page":"119","volume":"5","year":"2007","journal-title":"Journal of Supportive Oncology"},{"issue":"5","key":"48","first-page":"450S","volume":"20","year":"2001","journal-title":"Journal of the American College of Nutrition"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1186\/1756-9966-27-32"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1155\/2009\/689639"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1650"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2009.441"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2008.10.039"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1186\/jbiol50"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2007.06.019"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1675"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.4103\/0970-1591.44267"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.12327"},{"issue":"2","key":"59","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1080\/20786204.2009.10873823","volume":"51","year":"2009","journal-title":"South African Family Practice"},{"issue":"3","key":"60","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3747\/co.v13i3.88","volume":"13","year":"2006","journal-title":"Current Oncology"},{"issue":"2","key":"61","first-page":"176","volume":"232","year":"2007","journal-title":"Experimental Biology and Medicine"},{"key":"62","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-1776"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X08006545"},{"key":"84","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-006-0278-6"},{"key":"85","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-006-0350-2"},{"issue":"1","key":"68","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3747\/co.v13i1.77","volume":"13","year":"2006","journal-title":"Current Oncology"},{"key":"86","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.04.044"},{"issue":"2","key":"65","first-page":"152","volume":"5","year":"2000","journal-title":"Alternative Medicine Review"},{"issue":"1","key":"87","first-page":"153","volume":"4","year":"1998","journal-title":"Clinical Cancer Research"},{"key":"88","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(98)00185-2"},{"issue":"3","key":"66","first-page":"196","volume":"5","year":"2000","journal-title":"Alternative Medicine Review"},{"key":"89","doi-asserted-by":"publisher","DOI":"10.1007\/s002800050173"},{"issue":"3","key":"90","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/bjc.1989.68","volume":"59","year":"1989","journal-title":"British Journal of Cancer"},{"issue":"9","key":"91","first-page":"2474","volume":"62","year":"2002","journal-title":"Cancer Research"},{"key":"69","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2004.12.005"},{"issue":"3","key":"92","first-page":"1657","volume":"19","year":"1999","journal-title":"Anticancer Research"},{"issue":"4","key":"93","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1093\/jnci\/91.4.354","volume":"91","year":"1999","journal-title":"Journal of the National Cancer Institute"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1186\/1749-8546-4-20"},{"key":"94","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2007.08.025"},{"key":"95","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-004-0956-1"},{"key":"96","doi-asserted-by":"publisher","DOI":"10.1007\/s002040050539"},{"key":"97","doi-asserted-by":"publisher","DOI":"10.1139\/y04-049"},{"key":"98","doi-asserted-by":"publisher","DOI":"10.1211\/0022357044003"},{"key":"99","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2008.05.033"},{"key":"100","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(01)00761-3"},{"key":"101","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2006.01.028"},{"key":"102","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2003.11.002"},{"issue":"2","key":"103","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/bjc.1996.334","volume":"74","year":"1996","journal-title":"British Journal of Cancer"},{"key":"104","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2007.01.002"},{"issue":"3","key":"67","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1093\/jn\/135.3.525","volume":"135","year":"2005","journal-title":"Journal of Nutrition"},{"issue":"3","key":"70","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1093\/ajcn\/87.3.517","volume":"87","year":"2008","journal-title":"American Journal of Clinical Nutrition"},{"key":"71","doi-asserted-by":"publisher","DOI":"10.1124\/mol.106.030122"},{"issue":"2","key":"72","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1080\/07315724.2003.10719283","volume":"22","year":"2003","journal-title":"Journal of the American College of Nutrition"},{"issue":"3","key":"73","first-page":"303","volume":"8","year":"2003","journal-title":"Alternative Medicine Review"},{"key":"74","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.31.1270"},{"key":"75","first-page":"S3-17","volume":"19","year":"2009","journal-title":"Ethnicity & Disease"},{"issue":"5","key":"76","first-page":"319","volume":"55","year":"2005","journal-title":"CA: A Cancer Journal for Clinicians"},{"key":"77","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djn148"},{"issue":"5","key":"78","first-page":"464S","volume":"20","year":"2001","journal-title":"Journal of the American College of Nutrition"},{"issue":"5","key":"79","first-page":"280","volume":"29","year":"1979","journal-title":"CA: A Cancer Journal for Clinicians"},{"key":"80","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djn346"},{"issue":"1","key":"81","doi-asserted-by":"crossref","first-page":"22","DOI":"10.2174\/2212796810903010022","volume":"3","year":"2009","journal-title":"Current Chemical Biology"},{"key":"82","doi-asserted-by":"crossref","first-page":"e8","DOI":"10.1200\/JCO.2005.04.1327","volume":"24","year":"2006","journal-title":"Journal of Clinical Oncology"},{"key":"83","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2006.10.009"}],"container-title":["Chemotherapy Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/archive\/2012\/282570.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2012\/282570.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2012\/282570.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T03:00:51Z","timestamp":1643943651000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/cherp\/2012\/282570\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,20]]},"references-count":103,"alternative-id":["282570","282570"],"URL":"https:\/\/doi.org\/10.1155\/2012\/282570","relation":{},"ISSN":["2090-2107","2090-2115"],"issn-type":[{"value":"2090-2107","type":"print"},{"value":"2090-2115","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,20]]}}}