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Here, we used intravenous drug self-administration procedures in rats to further investigate the beneficial effects of electroacupuncture (EA) on heroin-seeking behavior in a reinstatement model of relapse. We trained Sprague-Dawley rats to nose-poke for i.v. heroin either daily for 4\u2009h or 25 infusions for 14 consecutive days. Then the rats were abstinent from heroin for two weeks. 2\u2009Hz EA stimulation was conducted once daily for 14\u2009days during heroin abstinence. We tested these animals for contextual and discrete cue-induced reinstatement of active responses. We also applied immunohistochemistry to detect Fos-positive nuclei in the nucleus accumbens (NACc) core and shell after reinstatement test. We found that active responses elicited by both contextual cues and discrete cues were high in the rats trained with heroin than in saline controls. EA treatment significantly reduced active responses elicited by discrete cues. EA stimulation attenuated Fos expression in the core but not the shell of the NACc. Altogether, these results highlight the therapeutic benefit of EA in preventing relapse to drug addiction.<\/jats:p>","DOI":"10.1155\/2012\/286404","type":"journal-article","created":{"date-parts":[[2012,2,14]],"date-time":"2012-02-14T16:01:09Z","timestamp":1329235269000},"page":"1-10","source":"Crossref","is-referenced-by-count":7,"title":["Electroacupuncture Suppresses Discrete Cue-Evoked Heroin-Seeking and Fos Protein Expression in the Nucleus Accumbens Core in Rats"],"prefix":"10.1155","volume":"2012","author":[{"given":"Sheng","family":"Liu","sequence":"first","affiliation":[{"name":"Ningbo Addiction Research and Treatment Center, School of Medicine, Ningbo University, Ningbo 315010, China"},{"name":"Laboratory of Acupuncture and Moxibustion, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fenglei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroscience, 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