{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T07:14:11Z","timestamp":1793949251067,"version":"4.8.0"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa de Minas Gerais"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical and Developmental Immunology"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>\n                    Parenteral injection of tolerated proteins into orally tolerant mice inhibits the initiation of immunological responses to unrelated proteins and blocks severe chronic inflammatory reactions of immunological origin, such as autoimmune reactions. This inhibitory effect which we have called \u201cindirect effects of oral tolerance\u201d is also known as \u201cbystander suppression.\u201d Herein, we show that i.p. injection of OVA + Al(OH)\n                    <jats:sub>3<\/jats:sub>\n                    minutes before i.v. injection of\n                    <jats:italic>Schistosoma mansoni<\/jats:italic>\n                    eggs into OVA tolerant mice blocked the increase of pulmonary granulomas. In addition, the expression of ICAM-1 in lung parenchyma in areas outside the granulomas of OVA-orally tolerant mice was significantly reduced. However, at day 18 after granuloma induction there was no difference in immunofluorescency intensity to CD3, CD4, F4\/80, and\n                    <jats:italic>\u03b1<\/jats:italic>\n                    -SMA per granuloma area of tolerant and control groups. Reduction of granulomas by reexposure to orally tolerated proteins was not correlated with a shift in Th-1\/Th-2 cytokines in serum or lung tissue extract.\n                  <\/jats:p>","DOI":"10.1155\/2012\/293625","type":"journal-article","created":{"date-parts":[[2011,10,13]],"date-time":"2011-10-13T15:02:10Z","timestamp":1318518130000},"page":"1-11","source":"Crossref","is-referenced-by-count":15,"title":["Indirect Effects of Oral Tolerance Inhibit Pulmonary Granulomas to\n                    <i>Schistosoma mansoni<\/i>\n                    Eggs"],"prefix":"10.1155","volume":"2012","author":[{"given":"Geraldo Magela","family":"Azevedo","sequence":"first","affiliation":[{"name":"Departamento de Morfologia, ICB-UFMG, Avenue Ant\u00f4nio Carlos 6627, Pampulha, Belo Horizonte, MG, CEP 31270-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel Alves","family":"Costa","sequence":"additional","affiliation":[{"name":"Departamento de Morfologia, ICB-UFMG, 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