{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:37:55Z","timestamp":1788305875015,"version":"build-2803163510"},"reference-count":46,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Autoimmune Diseases"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>Neonatal lupus erythematosus (NLE) refers to a clinical spectrum of cutaneous, cardiac, and systemic abnormalities observed in newborn infants whose mothers have autoantibodies against Ro\/SSA and La\/SSB. The condition is rare and usually benign and self-limited but sometimes may be associated with serious sequelae. We review the pathophysiology, clinical features, and management of infants with this condition. Neonates with NLE should be managed at a tertiary care center. Multidisciplinary team involvement may also be indicated. In mothers with anti-Ro\/SSA and\/or anti-La\/SSB antibodies and infants with congenital heart block, the risk of recurrence in subsequent offspring is 17\u201325%. Therefore, careful monitoring of subsequent pregnancies with serial ultrasonography and echocardiography is essential.<\/jats:p>","DOI":"10.1155\/2012\/301274","type":"journal-article","created":{"date-parts":[[2012,9,2]],"date-time":"2012-09-02T17:00:53Z","timestamp":1346605253000},"page":"1-6","source":"Crossref","is-referenced-by-count":38,"title":["Neonatal Lupus Erythematosus"],"prefix":"10.1155","volume":"2012","author":[{"given":"Kam","family":"Lun Hon","sequence":"first","affiliation":[{"name":"Department of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, 6\/F, Clinical Sciences Building, Shatin, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander K. 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