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However, depending on the subtype, patients with DLBCL still exhibit substantially different survival rates. In MCL, a mature B-cell lymphoma, the addition of rituximab to conventional chemotherapy regimens has increased response rates, but not survival. Burkitt lymphoma, the most aggressive BCL, is characterized by a high proliferative index and requires more intensive chemotherapy regimens than DLBCL. Hence, there is a need for more effective therapies for all three diseases. Increased understanding of the molecular features of aggressive BCL has led to the development of a range of novel therapies, many of which target the tumor in a tailored manner and are summarized in this paper.<\/jats:p>","DOI":"10.1155\/2012\/302570","type":"journal-article","created":{"date-parts":[[2012,3,25]],"date-time":"2012-03-25T21:01:21Z","timestamp":1332709281000},"page":"1-22","source":"Crossref","is-referenced-by-count":10,"title":["Novel Therapies for Aggressive B-Cell Lymphoma"],"prefix":"10.1155","volume":"2012","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2748-0986","authenticated-orcid":true,"given":"Kenneth A.","family":"Foon","sequence":"first","affiliation":[{"name":"Celgene Corporation, 86 Morris Avenue, Summit, NJ 07901, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Takeshita","sequence":"additional","affiliation":[{"name":"Celgene Corporation, 86 Morris Avenue, Summit, NJ 07901, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pier L.","family":"Zinzani","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncological Sciences \u201cL. e A. 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