{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:27:40Z","timestamp":1781051260136,"version":"3.54.1"},"reference-count":25,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology Research and Practice"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Pityriasis alba (PA) is a frequent cause of consultation in tropical areas due to its chronic course, frequent relapses, and notorious hypopigmented lesions in pediatric dark skin populations. Currently, no treatment is widely accepted.<jats:italic>Objective<\/jats:italic>. To assess the efficacy of 0.0003% calcitriol and 0.1% tacrolimus ointments compared with placebo in the treatment of endemic PA.<jats:italic>Methods<\/jats:italic>. Twenty-eight children aged 3\u201317 years with 56 symmetrical lesions and phototype IV-V, were randomly assigned to receive the treatments on target lesions on the face. Improvement was evaluated at baseline and 8 weeks later clinically and by digital quantification of the affected area, colorimetry, and transepidermal water loss (TEWL).<jats:italic>Results<\/jats:italic>. Tacrolimus and calcitriol ointments induced a mean improvement of 68%, compared to 44% of placebo. We found an elevated TEWL in PA lesions. In the treated plaques, the reduction of the affected area was associated with improvement of pigmentation and TEWL.<jats:italic>Conclusions<\/jats:italic>. Calcitriol and tacrolimus induced similar repigmentation in endemic PA lesions. Melanogenic, anti-inflammatory, and barrier defect restoration properties of these drugs may explain these findings.<\/jats:p>","DOI":"10.1155\/2012\/303275","type":"journal-article","created":{"date-parts":[[2012,4,22]],"date-time":"2012-04-22T21:01:26Z","timestamp":1335128486000},"page":"1-6","source":"Crossref","is-referenced-by-count":20,"title":["Double-Blind, Placebo-Controlled, Randomized Study Comparing 0.0003<b>%<\/b>Calcitriol with 0.1<b>%<\/b>Tacrolimus Ointments for the Treatment of Endemic Pityriasis Alba"],"prefix":"10.1155","volume":"2012","author":[{"given":"Berenice","family":"Moreno-Cruz","sequence":"first","affiliation":[{"name":"Dermatology Department, Hospital Central \u201cDr. Ignacio Morones Prieto\u201d, Universidad Aut\u00f3noma de San Luis Potos\u00ed, Avenida Carranza No. 2395, CP 78210, San Luis Potosi, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertha","family":"Torres-\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital Central \u201cDr. Ignacio Morones Prieto\u201d, Universidad Aut\u00f3noma de San Luis Potos\u00ed, Avenida Carranza No. 2395, CP 78210, San Luis Potosi, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Hern\u00e1ndez-Blanco","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital Central \u201cDr. Ignacio Morones Prieto\u201d, Universidad Aut\u00f3noma de San Luis Potos\u00ed, Avenida Carranza No. 2395, CP 78210, San Luis Potosi, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Pablo","family":"Castanedo-Cazares","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital Central \u201cDr. Ignacio Morones Prieto\u201d, Universidad Aut\u00f3noma de San Luis Potos\u00ed, Avenida Carranza 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