{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:28:56Z","timestamp":1773012536603,"version":"3.50.1"},"reference-count":55,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Inflammation"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>Interleukin 1<jats:italic>\u03b2<\/jats:italic>(IL-1<jats:italic>\u03b2<\/jats:italic>) is emerging as a master mediator of adult onset Still\u2019s disease (AOSD) pathogenesis. This pleiotropic cytokine, whose expression is under the control of the inflammasome pathway, has a wide type of effects. As a key mediator of innate immunity is a potent pyrogen and facilitates neutrophilic proliferation and diapedesis into the inflamed tissues, which are key AOSD manifestations. The study of proinflammatory cytokines profiles in sera and pathological tissues of AOSD patients has shown elevated levels of IL-1<jats:italic>\u03b2<\/jats:italic>, these levels being highly correlated with disease activity and severity. These experimental evidences and the analogy with other autoinflammatory diseases that share with AOSD clinical and biological characteristics have suggested the blockade of IL-1<jats:italic>\u03b2<\/jats:italic>as a possible new therapeutic option for the AOSD, especially in conventional therapy resistant cases. Anakinra, the first anti-IL-1 agent put on the market, has demonstrated capable to induce a rapid response sustained over time, especially in systemic forms, where anti-TNF<jats:italic>\u03b1<\/jats:italic>failed to control symptoms. While a growing number of evidences supports the utilisation of anakinra in AOSD, a new generation of anti-IL1<jats:italic>\u03b2<\/jats:italic>antagonists is developing. Canakinumab and rilonacept, thanks to their higher affinity and longer half-life, could improve the management of this invalidating disease.<\/jats:p>","DOI":"10.1155\/2012\/317820","type":"journal-article","created":{"date-parts":[[2012,4,29]],"date-time":"2012-04-29T21:01:15Z","timestamp":1335733275000},"page":"1-6","source":"Crossref","is-referenced-by-count":24,"title":["Anti-Interleukin-1 Agents in Adult Onset Still's Disease"],"prefix":"10.1155","volume":"2012","author":[{"given":"Cecilia","family":"Giampietro","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University of L\u2019Aquila, L\u2019Aquila, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Fautrel","sequence":"additional","affiliation":[{"name":"School of Medicine, University Paris 6-Pierre et Marie Curie, 75013 Paris, France"},{"name":"Department of Rheumatology, AP-HP, Piti\u00e9-Salp\u00eatri\u00e8re University Hospital, 75013 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200868030-00005"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2008.08.006"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.066381"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1038\/ncprheum0681"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.078014"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2010.03283.x"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2008.00730.x"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2011.02.004"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1002\/art.25006"},{"issue":"6","key":"10","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1182\/blood.V87.6.2095.bloodjournal8762095","volume":"87","year":"1996","journal-title":"Blood"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2010.4"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1038\/nature09447"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2007.09.009"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-08-236521"},{"key":"15","volume":"2012","year":"2012","journal-title":"International Journal of Inflammation"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keq284"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2011.01046.x"},{"issue":"6","key":"18","first-page":"821","volume":"140","year":"2011","journal-title":"Cell"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1106015108"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-07-273417"},{"issue":"2","key":"21","first-page":"396","volume":"25","year":"1998","journal-title":"The Journal of Rheumatology"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2007.04.002"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200868030-00005"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1080\/03009740701340081"},{"issue":"1","key":"25","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0091-6749(99)70518-X","volume":"103","year":"1999","journal-title":"Journal of Allergy and Clinical Immunology"},{"key":"26","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.2169\/internalmedicine.50.4771","volume":"50","year":"2011","journal-title":"Internal Medicine"},{"key":"27","volume":"63","year":"2011","journal-title":"Arthritis & Rheumatism"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keq397"},{"issue":"11","key":"29","first-page":"2189","volume":"31","year":"2004","journal-title":"Journal of Rheumatology"},{"issue":"5","key":"30","first-page":"939","volume":"35","year":"2008","journal-title":"Journal of Rheumatology"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2010.09.014"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.026617"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1002\/art.21061"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.076034"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.108068"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1186\/ar3366"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.024026"},{"key":"38","volume":"62","year":"2010","journal-title":"Arthritis & Rheumatism"},{"issue":"2","key":"39","first-page":"373","volume":"26","year":"1999","journal-title":"Journal of Rheumatology"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-010-1459-6"},{"issue":"5, supplement 27","key":"41","first-page":"S35","volume":"20","year":"2002","journal-title":"Clinical and Experimental Rheumatology"},{"key":"42","volume":"2, article cd008794","year":"2011","journal-title":"Cochrane Database of Systematic Reviews (Online)"},{"issue":"5","key":"43","first-page":"758","volume":"25","year":"2007","journal-title":"Clinical and Experimental Rheumatology"},{"issue":"4","key":"44","first-page":"892","volume":"34","year":"2007","journal-title":"Journal of Rheumatology"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2004.09.001"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.05074.x"},{"key":"47","first-page":"1831","volume":"62","year":"2010","journal-title":"Arthritis & Rheumatism"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.4161\/mabs.2.1.10328"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.11.001"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.05159.x"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0810787"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1002\/art.23687"},{"issue":"5","key":"53","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1111\/j.1365-2125.2011.03958.x","volume":"71","year":"2011","journal-title":"British Journal of Clinical Pharmacology"},{"issue":"6","key":"54","first-page":"755","volume":"12","year":"2010","journal-title":"Current Opinion in Molecular Therapeutics"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-155143"}],"container-title":["International Journal of Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/iji\/2012\/317820.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/iji\/2012\/317820.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/iji\/2012\/317820.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T21:52:06Z","timestamp":1594072326000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/iji\/2012\/317820\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":55,"alternative-id":["317820","317820"],"URL":"https:\/\/doi.org\/10.1155\/2012\/317820","relation":{},"ISSN":["2090-8040","2042-0099"],"issn-type":[{"value":"2090-8040","type":"print"},{"value":"2042-0099","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}