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Each of these categories have specific drugs dating back to the early 20th century, raising the question of whether or not we can find better bronchodilators. While caffeine, theophylline, atropine, and epinephrine were the first generations of therapeutics in each of these drug classes, there is no question that improvements have been made in the bronchodilators in each of these classes. In the following editorial, we will briefly describe new classes of potential bronchodilators including: novel PDE inhibitors, natural phytotherapeutics, bitter taste receptor ligands, and chloride channel modulators, which have the potential to be used alone or in combination with existing bronchodilators to reverse acute airway obstruction in the future.<\/jats:p>","DOI":"10.1155\/2012\/321949","type":"journal-article","created":{"date-parts":[[2012,10,2]],"date-time":"2012-10-02T23:26:40Z","timestamp":1349220400000},"page":"1-5","source":"Crossref","is-referenced-by-count":6,"title":["Can We Find Better Bronchodilators to Relieve Asthma Symptoms?"],"prefix":"10.1155","volume":"2012","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0818-0101","authenticated-orcid":true,"given":"Elizabeth A.","family":"Townsend","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, 650 W 168th Street, New York, NY 10032, 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