{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:21:56Z","timestamp":1765545716491},"reference-count":24,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Transplantation"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>Measurements of Cyclosporine (CsA) systemic exposure permit its dose adjustment in allogenic stem cell transplantation recipients to prevent graft-versus-host disease. CsA LSSs were developed and validated from 60 ASCT patients via multiple linear regressions. All whole-blood samples were analyzed by fluorescence polarization immunoassay (FPIA-Axym). The 10 models that have used CsA concentrations at a single time point did not have a good fit with AUC<jats:sub>0\u201312<\/jats:sub>(). and were the time points that correlated best with AUC<jats:sub>0\u201312\u2009h<\/jats:sub>, were respectively 0.848, and 0.897. The LSS equation with the best predictive performance (bias, precision and number of samples) utilized three sampling concentrations was AUC<jats:sub>0\u201312\u2009h<\/jats:sub>. Optimal LSSs equations which limited to those utilizing three timed concentrations taken within 4 hours post-dose developed from ASCT recipient's patients yielded a low bias &lt;5% ranged from 1.27% to 2.68% and good precision &lt;15% ranged from 9.60% and 11.02%. We propose an LSS model with equation AUC<jats:sub>0\u201312\u2009h<\/jats:sub>for a practical reason. Bias and precision for this model are respectively 2.68% and 11.02%.<\/jats:p>","DOI":"10.1155\/2012\/342701","type":"journal-article","created":{"date-parts":[[2011,10,26]],"date-time":"2011-10-26T15:01:11Z","timestamp":1319641271000},"page":"1-7","source":"Crossref","is-referenced-by-count":6,"title":["Estimation of Abbreviated Cyclosporine A Area under the Concentration-Time Curve in Allogenic Stem Cell Transplantation after Oral Administration"],"prefix":"10.1155","volume":"2012","author":[{"given":"Hanene","family":"ELjebari","sequence":"first","affiliation":[{"name":"Laboratoire de Pharmacologie Clinique, Centre National de Pharmacovigilance, 9 Avenue Dr. Zouhe\u00efr Essafi, Tunis 1006, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Ben Fradj","sequence":"additional","affiliation":[{"name":"Laboratoire de Pharmacologie Clinique, Centre National de Pharmacovigilance, 9 Avenue Dr. Zouhe\u00efr Essafi, Tunis 1006, 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