{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:25:52Z","timestamp":1772670352070,"version":"3.50.1"},"reference-count":39,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Diabetes Research"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. Many patients with non-alcoholic fatty liver disease (NAFLD) have impaired glucose regulation or type 2 diabetes mellitus (DM). We investigated characteristics of NAFLD patients associated with hyperglycemia.<jats:italic>Methods<\/jats:italic>. During a 2-hour oral glucose tolerance test (OGTT), serum glucose and insulin were measured in 152 NAFLD patients.<jats:italic>Results<\/jats:italic>. 48.7% of NAFLD patients had hyperglycemia. Age (odds ratio<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mo>(<\/mml:mo><mml:mrow><mml:mtext>OR<\/mml:mtext><\/mml:mrow><mml:mo>)<\/mml:mo><\/mml:mrow><mml:mo>=<\/mml:mo><mml:mn>1.08<\/mml:mn><\/mml:math>, 95% confidence interval (CI): 1.03\u20131.13), body mass index (BMI) (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mtext>OR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>1.12<\/mml:mn><\/mml:math>, 95% CI: 1.01\u20131.25), and lower high-density lipoprotein cholesterol (HDL-C) (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mtext>OR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>0.95<\/mml:mn><\/mml:math>, 95% CI: 0.92\u20130.98) proved to be independent predictors of hyperglycemia. After OGTT, 30\u2009min insulin was lower in hyperglycemic patients (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mn>74.2<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>49.7<\/mml:mn><\/mml:math>versus<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mn>94.5<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>53.9<\/mml:mn><\/mml:math>\u2009\u03bcIU\/mL,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.02<\/mml:mn><\/mml:math>), while 90\u2009min insulin (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mn>170.1<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>84.6<\/mml:mn><\/mml:math>versus<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mn>122.9<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>97.7<\/mml:mn><\/mml:math>\u2009\u03bcU\/mL,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:math>) and 120\u2009min insulin (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mn>164.0<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>101.2<\/mml:mn><\/mml:math>versus<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mn>85.3<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>61.9<\/mml:mn><\/mml:math>\u2009\u03bcIU\/mL,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:math>) were higher.<jats:italic>Conclusions<\/jats:italic>. NAFLD patients with higher BMI, lower HDL-C, or older age were more likely to have impaired glucose metabolism. An OGTT could be of value for early diagnosis of DM among this population.<\/jats:p>","DOI":"10.1155\/2012\/351974","type":"journal-article","created":{"date-parts":[[2011,9,21]],"date-time":"2011-09-21T19:46:10Z","timestamp":1316634370000},"page":"1-7","source":"Crossref","is-referenced-by-count":14,"title":["Predictors of Impaired Glucose Regulation in Patients with Non-Alcoholic Fatty Liver Disease"],"prefix":"10.1155","volume":"2012","author":[{"given":"Erifili","family":"Hatziagelaki","sequence":"first","affiliation":[{"name":"2nd Department of Internal Medicine, Research Institute and Diabetes Center, University of Athens Medical School, Attikon University Hospital, 12462 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Drosos E.","family":"Karageorgopoulos","sequence":"additional","affiliation":[{"name":"Alfa Institute of Biomedical Sciences (AIBS), Marousi, 15123 Athens, 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