{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T13:37:04Z","timestamp":1773149824626,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Endocrinology"],"published-print":{"date-parts":[[2012]]},"abstract":"\n Objective<\/jats:italic>\n . To report the prestimulation use of adjuvant GH for gonadotropin ovulation induction in a woman with hypopituitarism and GH deficiency who previously failed to respond.\n Design, Patients, and Measurements<\/jats:italic>\n . A 31-year-old nulliparous woman presented with hypopituitarism and GH deficiency after failing ovulation induction with high dose gonadotropins. A trial of GH was undertaken for 5 months prior to ovulation induction resulting in normalization of IGF-I levels.\n Results<\/jats:italic>\n . Women with hypopituitarism are known to have lower pregnancy rates after ovulation induction with need for higher doses of gonadotropins. A small subset of these patients do not ovulate. This patient had successful ovulation induction and pregnancy with prestimulation GH.\n Conclusions<\/jats:italic>\n . This case suggests that the use of adjuvant GH in a GH-deficient patient several months before the use of human menopausal gonadotropin results in ovulation and pregnancy.\n <\/jats:p>","DOI":"10.1155\/2012\/356429","type":"journal-article","created":{"date-parts":[[2012,7,31]],"date-time":"2012-07-31T17:00:35Z","timestamp":1343754035000},"page":"1-3","source":"Crossref","is-referenced-by-count":3,"title":["Adjuvant Growth Hormone for Ovulation Induction with Gonadotropins in the Treatment of a Woman with Hypopituitarism"],"prefix":"10.1155","volume":"2012","author":[{"given":"Ariadne","family":"Daniel","sequence":"first","affiliation":[{"name":"Department of Reproductive Endocrinology and Infertility, Mount Sinai Center for Fertility and Reproductive Health, 250 Dundas Street West, Suite 700, Toronto, ON, Canada M5T 2Z5"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shereen","family":"Ezzat","sequence":"additional","affiliation":[{"name":"Division of Endocrine Oncology, University Health Network, 585 University Avenue, Toronto, ON, Canada M5N 2N2"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen","family":"Greenblatt","sequence":"additional","affiliation":[{"name":"Department of Reproductive Endocrinology and Infertility, Mount Sinai Center for Fertility and Reproductive Health, 250 Dundas Street West, Suite 700, Toronto, ON, Canada M5T 2Z5"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.12.077"},{"issue":"1","key":"2","year":"2010","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2011.09.049"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(00)00599-9"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2006.02550.x"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1080\/09513590601137533"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2010.08.022"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2011.06.011"},{"issue":"11","key":"9","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1093\/oxfordjournals.humrep.a138381","volume":"9","year":"1994","journal-title":"Human Reproduction"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1210\/jc.84.2.590"},{"issue":"5","key":"11","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/S0015-0282(16)57902-3","volume":"64","year":"1995","journal-title":"Fertility and Sterility"},{"issue":"2","key":"12","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/S0015-0282(16)60864-6","volume":"52","year":"1989","journal-title":"Fertility and Sterility"},{"issue":"6","key":"13","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1111\/j.1365-2265.1990.tb00925.x","volume":"32","year":"1990","journal-title":"Clinical Endocrinology"},{"issue":"7","key":"14","first-page":"381","volume":"117","year":"1995","journal-title":"Zentralblatt fur Gynakologie"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(00)01619-8"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.09.065"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-0179"}],"container-title":["Case Reports in Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crie\/2012\/356429.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crie\/2012\/356429.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crie\/2012\/356429.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,20]],"date-time":"2017-06-20T18:15:51Z","timestamp":1497982551000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/crie\/2012\/356429\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":17,"alternative-id":["356429","356429"],"URL":"https:\/\/doi.org\/10.1155\/2012\/356429","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.717967408.793467063","asserted-by":"object"}]},"ISSN":["2090-6501","2090-651X"],"issn-type":[{"value":"2090-6501","type":"print"},{"value":"2090-651X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}