{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T11:21:39Z","timestamp":1648639299074},"reference-count":10,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Immunology"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>Up to now the exposures to hair and skin derivatives of animals have not yet been the subject of systematic studies. The observation of a clinical case has provided the opportunity for a review of the literature. The inpatient was a 49-year-old man, a carder in a textile factory, exposed to angora wool. He noticed the appearance of dyspnea during working hours. There was no eosinophilia in blood, and the results of pulmonary function tests were normal. The nonspecific bronchial provocation test with methacholine demonstrated an abnormal bronchial reactivity. The challenge test with angora wool was positive (decrease in FEV1 of more than 40%) as well as total IGE and specific IgE to rabbit epithelium (433\u2009KU\/l and 12.1\u2009KUA\/l, resp.). Several sources of allergens were found in the rabbit, and the main allergen was represented by proteins from epithelia, urine, and saliva. Most of these proteins belong to the family of lipocalin, they function as carriers for small hydrophobic molecules (vitamins and pheromones). If the diagnosis of occupational asthma caused by animal hair and skin derivatives may be relatively easy by means of the challenge test, defining etiology is complicated because of the lack of in vitro tests.<\/jats:p>","DOI":"10.1155\/2012\/358271","type":"journal-article","created":{"date-parts":[[2012,9,23]],"date-time":"2012-09-23T21:00:14Z","timestamp":1348434014000},"page":"1-3","source":"Crossref","is-referenced-by-count":0,"title":["Angora Wool Asthma in Textile Industry"],"prefix":"10.1155","volume":"2012","author":[{"given":"Pietro","family":"Sartorelli","sequence":"first","affiliation":[{"name":"Unit of Occupational Medicine and Toxicology, University of Siena, 16 Bracci Avenue, 53100 Siena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riccardo","family":"Romeo","sequence":"additional","affiliation":[{"name":"Unit of Occupational Medicine and Toxicology, University of Siena, 16 Bracci Avenue, 53100 Siena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppina","family":"Coppola","sequence":"additional","affiliation":[{"name":"Unit of Occupational Medicine and Toxicology, University of Siena, 16 Bracci Avenue, 53100 Siena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Nuti","sequence":"additional","affiliation":[{"name":"Unit of Occupational Medicine and Toxicology, University of Siena, 16 Bracci Avenue, 53100 Siena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Paolucci","sequence":"additional","affiliation":[{"name":"Unit of Occupational Medicine and Toxicology, University of Siena, 16 Bracci Avenue, 53100 Siena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"issue":"1","key":"2","first-page":"41","volume":"49","year":"1992","journal-title":"British Journal of Industrial Medicine"},{"key":"1","first-page":"3","volume":"3","year":"1982","journal-title":"Fisiop Resp"},{"issue":"1","key":"7","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1365-2222.1986.tb01953.x","volume":"16","year":"1986","journal-title":"Clinical Allergy"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1136\/oem.2008.044727"},{"issue":"5","key":"3","first-page":"133","volume":"55","year":"1977","journal-title":"Klinicheskaya Meditsina"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2001.00973.x"},{"issue":"1","key":"10","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1093\/ilar.42.1.12","volume":"42","year":"2001","journal-title":"ILAR Journal"},{"issue":"4","key":"9","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1159\/000024277","volume":"120","year":"1999","journal-title":"International Archives of Allergy and Immunology"},{"issue":"1","key":"5","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1093\/ilar.44.1.28","volume":"44","year":"2003","journal-title":"ILAR Journal"},{"issue":"8","key":"8","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1111\/j.1398-9995.1986.tb00353.x","volume":"41","year":"1986","journal-title":"Allergy"}],"container-title":["Case Reports in Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crii\/2012\/358271.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crii\/2012\/358271.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crii\/2012\/358271.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T00:34:19Z","timestamp":1498005259000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/crii\/2012\/358271\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":10,"alternative-id":["358271","358271"],"URL":"https:\/\/doi.org\/10.1155\/2012\/358271","relation":{},"ISSN":["2090-6609","2090-6617"],"issn-type":[{"value":"2090-6609","type":"print"},{"value":"2090-6617","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}