{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:29:01Z","timestamp":1791217741677,"version":"4.1.0"},"reference-count":62,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Pediatrics"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>Meconium aspiration syndrome (MAS) is a common cause of severe respiratory distress in term infants, with an associated highly variable morbidity and mortality. MAS results from aspiration of meconium during intrauterine gasping or during the first few breaths. The pathophysiology of MAS is multifactorial and includes acute airway obstruction, surfactant dysfunction or inactivation, chemical pneumonitis with release of vasoconstrictive and inflammatory mediators, and persistent pulmonary hypertension of newborn (PPHN). This disorder can be life threatening, often complicated by respiratory failure, pulmonary air leaks, and PPHN. Approaches to the prevention of MAS have changed over time with collaboration between obstetricians and pediatricians forming the foundations for care. The use of surfactant and inhaled nitric oxide (iNO) has led to the decreased mortality and the need for extracorporeal membrane oxygenation (ECMO) use. In this paper, we review the current understanding of the pathophysiology and management of MAS.<\/jats:p>","DOI":"10.1155\/2012\/359571","type":"journal-article","created":{"date-parts":[[2011,11,22]],"date-time":"2011-11-22T21:18:01Z","timestamp":1321996681000},"page":"1-7","source":"Crossref","is-referenced-by-count":63,"title":["Advances in the Management of Meconium Aspiration Syndrome"],"prefix":"10.1155","volume":"2012","author":[{"given":"Kamala","family":"Swarnam","sequence":"first","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, University of Calgary, Calgary, AB, Canada T2N 1N4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amuchou S.","family":"Soraisham","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, University of Calgary, Calgary, AB, Canada T2N 1N4"},{"name":"Alberta Children's Hospital Research Institute for Child and Maternal Health, University of Calgary, Calgary, AB, Canada T2N 4N1"},{"name":"Department of Pediatrics, Foothills Medical Centre, Rm C211 1403-29th Street NW, Calgary, AB, Canada T2N 2T9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sindhu","family":"Sivanandan","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, University of Calgary, Calgary, AB, Canada T2N 1N4"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","reference":[{"issue":"5","key":"1","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1542\/peds.85.5.715","volume":"85","year":"1990","journal-title":"Pediatrics"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-3955(05)70025-0"},{"issue":"3","key":"3","first-page":"329","volume":"83","year":"1994","journal-title":"Obstetrics & Gynecology"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe058149"},{"issue":"3","key":"5","doi-asserted-by":"crossref","first-page":"275","DOI":"10.3109\/00016348209156571","volume":"61","year":"1982","journal-title":"Acta Obstetricia et Gynecologica Scandinavica"},{"issue":"2","key":"6","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0002-9378(88)90134-2","volume":"158","year":"1988","journal-title":"American Journal of Obstetrics & Gynecology"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-3955(05)70025-0"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-2215"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2005.11.014"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.obstetgynecol.2003.07.006"},{"issue":"5","key":"11","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/BF02723617","volume":"70","year":"2003","journal-title":"The Indian Journal of Pediatrics"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(02)01942-7"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-2426"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.115120"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.116828"},{"issue":"4","key":"16","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1097\/00003246-198504000-00005","volume":"13","year":"1985","journal-title":"Critical Care Medicine"},{"issue":"2","key":"17","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0002-9378(11)80003-7","volume":"164","year":"1991","journal-title":"American Journal of Obstetrics & Gynecology"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2010.12.3715"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0378(99)00048-0"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1097\/01.ogx.0000149659.89530.c2"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2000.105821"},{"issue":"4","key":"22","first-page":"652","volume":"73","year":"1989","journal-title":"Obstetrics & Gynecology"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-11-S3-S5"},{"issue":"3","key":"24","year":"2006","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(98)80021-5"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(99)00629-8"},{"issue":"1","key":"27","year":"2010","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"4","key":"28","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1097\/00006250-200610000-00048","volume":"108","year":"2006","journal-title":"Obstetrics & Gynecology"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16852-9"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.971127"},{"key":"31","year":"2010"},{"issue":"1","key":"32","year":"2001","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2008.156"},{"issue":"1","key":"34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1542\/peds.105.1.1","volume":"105","year":"2000","journal-title":"Pediatrics"},{"issue":"5","key":"35","first-page":"657","volume":"81","year":"1988","journal-title":"Pediatrics"},{"issue":"12","key":"36","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1097\/00003246-198512000-00005","volume":"13","year":"1985","journal-title":"Critical Care Medicine"},{"issue":"3","key":"37","doi-asserted-by":"crossref","first-page":"92S","DOI":"10.1378\/chest.105.3_Supplement.92S","volume":"105","year":"1994","journal-title":"Chest"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(97)70124-0"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1053\/rmed.2001.1114"},{"issue":"10","key":"40","first-page":"109","volume":"2","year":"2004","journal-title":"Paediatrics and Child Health"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002054.pub2"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1542\/peds.109.6.1081"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.08.044"},{"issue":"1","key":"44","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/S0022-3476(77)80789-0","volume":"90","year":"1977","journal-title":"Journal of Pediatrics"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0496(1999)27:18+<205::AID-PPUL66>3.0.CO;2-0"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003485"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fmm035"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fml018"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-011-1453-2"},{"issue":"2","key":"50","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1542\/peds.89.2.203","volume":"89","year":"1992","journal-title":"Pediatrics"},{"issue":"3","key":"51","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/BF02753596","volume":"62","year":"1995","journal-title":"The Indian Journal of Pediatrics"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1159\/000081086"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1179\/146532807X192471"},{"issue":"5, article e7","key":"54","volume":"100","year":"1997","journal-title":"Pediatrics"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(97)70124-0"},{"issue":"10","key":"56","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1177\/039139889501801002","volume":"18","year":"1995","journal-title":"International Journal of Artificial Organs"},{"issue":"3","key":"57","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0022-3476(94)70354-X","volume":"124","year":"1994","journal-title":"Journal of Pediatrics"},{"issue":"1920","key":"58","first-page":"75","volume":"348","year":"1996","journal-title":"The Lancet"},{"issue":"1, part 1","key":"59","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1542\/peds.105.1.14","volume":"105","year":"2000","journal-title":"Pediatrics"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2004.04.001"},{"issue":"3","key":"61","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1203\/PDR.0b013e3181ebd4c3","volume":"68","year":"2010","journal-title":"Pediatric Research"},{"key":"62","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2008.149"}],"container-title":["International Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijpedi\/2012\/359571.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijpedi\/2012\/359571.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijpedi\/2012\/359571.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T17:35:11Z","timestamp":1639762511000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/ijpedi\/2012\/359571\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":62,"alternative-id":["359571","359571"],"URL":"https:\/\/doi.org\/10.1155\/2012\/359571","relation":{},"ISSN":["1687-9740","1687-9759"],"issn-type":[{"value":"1687-9740","type":"print"},{"value":"1687-9759","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}