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Adult male Wistar rats were given vehicle, single i.p. dose of CIS alone (10\u2009mg\/kg), GB alone (200\u2009mg\u2009g\/kg every day for five days), or single dose of CIS followed by GB (50, 100, or 200\u2009mg\/kg every day for five days). On day 6, after the first drug treatment oxidative and apoptotic testicular toxicity was evaluated. CIS-treated rats displayed decreased weights of testes and epididymis as well as caudal sperm count and motility. This reproductive toxicity was accompanied with increased germ-cell degeneration in seminiferous tubules and increased germ-cell apoptosis, increased testicular MDA levels and MPO activity, and decreased SOD and CAT activities in testes. Intensive expressions of COX-2, iNOS, and NF-\u03baB p65 in testicular tissues were detected in CIS-treated group. Oral GB administrations at all doses to CIS-treated rats effectively alleviated all of the CIS-induced toxicity in reproductive system. The present results provide further insights into the mechanisms of protection against CIS-induced reproductive toxicity and confirm the essential antioxidant potential of a GB extract.<\/jats:p>","DOI":"10.1155\/2012\/362049","type":"journal-article","created":{"date-parts":[[2012,5,29]],"date-time":"2012-05-29T07:10:57Z","timestamp":1338275457000},"page":"1-11","source":"Crossref","is-referenced-by-count":37,"title":["A Standardized Extract of<i>Ginkgo biloba<\/i>Neutralizes Cisplatin-Mediated Reproductive Toxicity in Rats"],"prefix":"10.1155","volume":"2012","author":[{"given":"Amr","family":"Amin","sequence":"first","affiliation":[{"name":"Biology Department, United Arab Emirates University, Al Ain 17551, UAE"},{"name":"Zoology Department, Cairo University, Giza, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christeena","family":"Abraham","sequence":"additional","affiliation":[{"name":"Biology Department, United Arab Emirates University, Al Ain 17551, 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