{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T19:20:11Z","timestamp":1761765611029},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Schizophrenia Research and Treatment"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p><jats:italic>Background and Goal<\/jats:italic>. The aim was to examine the serum levels of homocysteine (Hcy) and their associations with the methylenetetrahydrofolate reductase (<jats:italic>MTHFR<\/jats:italic>) gene C677T polymorphism in patients with schizophrenia and mood disorders as well as controls.<jats:italic>Materials and Methods<\/jats:italic>. There were 198 patients: 82 with schizophrenia spectrum disorders, 22 with mood disorders, and 94 controls. The level of Hcy was determined by an isocratic high-performance liquid chromatography system.<jats:italic>MTHFR<\/jats:italic>C677T polymorphism was analysed using the restriction fragment length polymorphism-polymerase chain reaction method.<jats:italic>Results<\/jats:italic>. The average level of Hcy was<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mn>11.94<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>5.6<\/mml:mn><mml:mo>\u2009<\/mml:mo><\/mml:math><jats:italic>\u03bc<\/jats:italic>mol\/L for patients with schizophrenia,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mn>11.65<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>3.3<\/mml:mn><mml:mo>\u2009<\/mml:mo><\/mml:math><jats:italic>\u03bc<\/jats:italic>mol\/L for patients with affective disorders, versus<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mn>6.80<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>2.93<\/mml:mn><mml:mo>\u2009<\/mml:mo><\/mml:math><jats:italic>\u03bc<\/jats:italic>mol\/L in a control. The highest level of Hcy has been observed in patients with episodic-recurrent course of schizophrenia (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mn>11.30<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>7.74<\/mml:mn><mml:mo>\u2009<\/mml:mo><\/mml:math><jats:italic>\u03bc<\/jats:italic>mol\/L), paranoid schizophrenia continuous (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mn>12.76<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>5.25<\/mml:mn><mml:mo>\u2009<\/mml:mo><\/mml:math><jats:italic>\u03bc<\/jats:italic>mol\/L), and in patients with affective disorders (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mn>11.65<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>3.26<\/mml:mn><mml:mo>\u2009<\/mml:mo><\/mml:math><jats:italic>\u03bc<\/jats:italic>mol\/L). An association between the<jats:italic>MTHFR<\/jats:italic>gene C677T polymorphism and Hcy level was found by linear regression analysis (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mi>r<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>1.41<\/mml:mn><\/mml:math>,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.029<\/mml:mn><\/mml:math>).<jats:italic>Conclusions<\/jats:italic>. The data indicate a link between Hcy levels and schizophrenia and mood disorders. No associations between the level of Hcy in patients with schizophrenia and mood disorders and the<jats:italic>MTHFR<\/jats:italic>C677T polymorphism were found.<\/jats:p>","DOI":"10.1155\/2012\/373261","type":"journal-article","created":{"date-parts":[[2012,10,2]],"date-time":"2012-10-02T23:26:52Z","timestamp":1349220412000},"page":"1-7","source":"Crossref","is-referenced-by-count":16,"title":["Elevated Serum Levels of Homocysteine as an Early Prognostic Factor of Psychiatric Disorders in Children and Adolescents"],"prefix":"10.1155","volume":"2012","author":[{"given":"Laura","family":"Kevere","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Narcology, Riga Stradins University, 215-27 Maskavas Street, 1019 Riga, Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santa","family":"Purvina","sequence":"additional","affiliation":[{"name":"Department of Internal Diseases, Riga Stradins University (RSU), 13 Pilsonu Street, 1002 Riga, 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