{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T15:24:21Z","timestamp":1760369061411},"reference-count":31,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Autoimmune Diseases"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>Autoimmune thyroid diseases (ATDs) represent the most frequent forms of the organ-specific autoimmune thyroid disorders that result from interaction between genetic and environmental factors. Selenium has been shown to exert a beneficial effect on the autoimmune thyroiditis. In spite of therapeutical effect of selenium on autoimmunity, the mechanism of its action has not been revealed.<jats:italic>Objective<\/jats:italic>. To determine whether selenium in vitro thyrocytes cultures are able to influence the HLA-DR molecule expression of human thyrocytes and production of free oxygen radicals.<jats:italic>Method<\/jats:italic>. Thyrocytes were prepared from human thyroid gland and cultured in vitro in the presence of interferon-<jats:italic>\u03b3<\/jats:italic>and sodium selenite. The expression of HLA-DR molecules induced by interferon-<jats:italic>\u03b3<\/jats:italic>in the presence of sodium selenite of various concentration was measured by fluorescence-activated cell sorter.<jats:italic>Results<\/jats:italic>. Selenium has a dose-dependent inhibitory effect on the expression of HLA-DR molecules of thyrocytes induced by interferon-<jats:italic>\u03b3<\/jats:italic>. This effect of selenium was in the inverse correlation with antioxidative capacity.<jats:italic>Conclusion<\/jats:italic>. Beneficial effect of selenium on autoimmune mechanism is a complex mechanism in which the inhibitory effect on HLA-DR molecule expression and antioxidative capacity are involved into therapy of autoimmune thyroiditis.<\/jats:p>","DOI":"10.1155\/2012\/374635","type":"journal-article","created":{"date-parts":[[2012,2,2]],"date-time":"2012-02-02T21:00:25Z","timestamp":1328216425000},"page":"1-5","source":"Crossref","is-referenced-by-count":3,"title":["Effect of Selenium on HLA-DR Expression of Thyrocytes"],"prefix":"10.1155","volume":"2012","author":[{"given":"Csaba","family":"Bal\u00e1zs","sequence":"first","affiliation":[{"name":"Department of Medicine and Endocrinology, Polyclinic of the Hospitaller Brother of St. John of God in Budapest, Budapest 1027, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vikt\u00f3ria","family":"Kaczur","sequence":"additional","affiliation":[{"name":"Department of Medicine and Endocrinology, Polyclinic of the Hospitaller Brother of 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