{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T12:15:19Z","timestamp":1790943319354,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p><jats:italic>Calendula officinalis<\/jats:italic>is an annual herb from Mediterranean origin which is popularly used in wound healing and as an anti-inflammatory agent. In this study, the ethanolic extract, the dichloromethane, and hexanic fractions of the flowers from plants growing in Brazil were produced. The angiogenic activity of the extract and fractions was evaluated through the chorioallantoic membrane and cutaneous wounds in rat models. The healing activity of the extract was evaluated by the same cutaneous wounds model through macroscopic, morphometric, histopathologic, and immunohistochemical analysis. The antibacterial activity of the extract and fractions was also evaluated. This experimental study revealed that<jats:italic>C. officinalis<\/jats:italic>presented anti-inflammatory and antibacterial activities as well as angiogenic and fibroplastic properties acting in a positive way on the inflammatory and proliferative phases of the healing process.<\/jats:p>","DOI":"10.1155\/2012\/375671","type":"journal-article","created":{"date-parts":[[2012,1,24]],"date-time":"2012-01-24T16:01:22Z","timestamp":1327420882000},"page":"1-7","source":"Crossref","is-referenced-by-count":108,"title":["Wound Healing and Anti-Inflammatory Effect in Animal Models of<i>Calendula officinalis<\/i>L. Growing in Brazil"],"prefix":"10.1155","volume":"2012","author":[{"given":"Leila Maria Leal","family":"Parente","sequence":"first","affiliation":[{"name":"Laboratory of Natural Products, Pharmacy Faculty, Federal University of Goi\u00e1s, 74605-220 Goi\u00e2nia, GO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruy de Souza","family":"Lino J\u00fanior","sequence":"additional","affiliation":[{"name":"Department of General Pathology, Institute of Tropical Pathology and Public Health, Federal University of Goi\u00e1s, 74605-050 Goi\u00e2nia, GO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonice Manrique Faustino","family":"Tresvenzol","sequence":"additional","affiliation":[{"name":"Laboratory of Natural Products, Pharmacy Faculty, Federal University of Goi\u00e1s, 74605-220 Goi\u00e2nia, GO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina Clare","family":"Vinaud","sequence":"additional","affiliation":[{"name":"Department of General Pathology, Institute of Tropical Pathology and Public Health, Federal University of Goi\u00e1s, 74605-050 Goi\u00e2nia, GO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Realino","family":"de Paula","sequence":"additional","affiliation":[{"name":"Laboratory of Natural Products, Pharmacy Faculty, Federal University of Goi\u00e1s, 74605-220 Goi\u00e2nia, GO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neusa Margarida","family":"Paulo","sequence":"additional","affiliation":[{"name":"Veterinary School, Federal University of Goi\u00e1s, 74001-970 Goi\u00e2nia, GO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1006\/anbo.2000.1322"},{"key":"2","year":"2010"},{"key":"3","year":"2002"},{"key":"4","year":"1998"},{"issue":"11","key":"5","first-page":"1401","volume":"134","year":"1998","journal-title":"Archives of Dermatology"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2009.02.016"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/S0367-326X(03)00051-0"},{"issue":"7","key":"8","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1248\/cpb.49.863","volume":"49","year":"2001","journal-title":"Chemical Pharmaceutical Bulletin"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1002\/pca.739"},{"key":"10","first-page":"658","volume":"56","year":"1990","journal-title":"Planta M\u00e9dica"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-959562"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(97)00061-5"},{"issue":"1","key":"13","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0944-7113(96)80004-3","volume":"3","year":"1996","journal-title":"Phytomedicine"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-40422007000200026"},{"key":"15","year":"2001"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2007.04.019"},{"key":"17","year":"1977"},{"issue":"1","key":"18","doi-asserted-by":"crossref","first-page":"73","DOI":"10.2174\/1389201003379040","volume":"1","year":"2000","journal-title":"Current Pharmaceutical Biotechnology"},{"key":"19","first-page":"7","volume":"18","year":"2006","journal-title":"Revista de Odontologia da Universidade Cidade de S\u00e3o Paulo"},{"key":"20","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.jep.2005.02.019","volume":"99","year":"2005","journal-title":"Journal of Ethnopharmacology"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-86502006000900009"},{"issue":"1","key":"22","first-page":"61","volume":"7","year":"2000","journal-title":"Revista da Faculdade de Zootecnia, Veterin\u00e1ria e Agronomia"},{"issue":"8","key":"23","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1177\/33.8.2410480","volume":"33","year":"1985","journal-title":"Journal of Histochemistry and Cytochemistry"},{"issue":"2","key":"24","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1590\/S0100-69912006000200004","volume":"33","year":"2006","journal-title":"Revista do Col\u00e9gio Brasileiro de Cirurgi\u00f5es"},{"issue":"1","key":"26","doi-asserted-by":"crossref","first-page":"73","DOI":"10.2174\/1389201003379040","volume":"1","year":"2000","journal-title":"Current Pharmaceutical Biotechnology"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2009.09.014"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1038\/74651"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1038\/nm0603-653"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2005.07.001"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2012\/375671.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2012\/375671.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2012\/375671.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,22]],"date-time":"2019-06-22T17:46:18Z","timestamp":1561225578000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/ecam\/2012\/375671\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":29,"alternative-id":["375671","375671"],"URL":"https:\/\/doi.org\/10.1155\/2012\/375671","relation":{},"ISSN":["1741-427X","1741-4288"],"issn-type":[{"value":"1741-427X","type":"print"},{"value":"1741-4288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}