{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T23:12:02Z","timestamp":1762297922264,"version":"3.37.3"},"reference-count":13,"publisher":"Wiley","license":[{"start":{"date-parts":[[2012,12,16]],"date-time":"2012-12-16T00:00:00Z","timestamp":1355616000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100003762","name":"Institut Pasteur","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003762","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Malaria Research and Treatment"],"published-print":{"date-parts":[[2012,12,16]]},"abstract":"The initial success of any adopted anti-infective strategy to malaria is followed by a descent due to the emergence of resistance to it. The search for new drugs and drug targets is a consistent demand in this disease. Eosin B, a common laboratory dye, is reported to have good antiparasitic properties in vitro<\/jats:italic>. It was studied for its antiparasitic effect in vivo <\/jats:italic>on chloroquine-sensitive Plasmodium berghei <\/jats:italic>murine malaria. Eosin B was administered in 2 different doses by either the oral or parenteral route, once or twice daily to mice infected with Plasmodium berghei<\/jats:italic>. Both the doses of eosin B 400\u2009mg\/kg and 800\u2009mg\/kg gave better results than the controls which were 40\u2009mg\/kg chloroquine and 100\u2009mg\/kg of arteether with P<\/mml:mi><<\/mml:mo>0<\/mml:mn>.<\/mml:mo>005<\/mml:mn><\/mml:math> significance. Percentage suppressive activity by Peter\u2019s test of eosin B was better, though at a higher dose than both the controls. Survival rate of mice receiving the higher dose of eosin B was longer than that of the controls. When administered twice daily, the mice were fully cured after 4 days. Eosin B seems to be a promising drug exhibiting good antimalarial effects in the murine model of the disease.<\/jats:p>","DOI":"10.1155\/2012\/381724","type":"journal-article","created":{"date-parts":[[2012,12,16]],"date-time":"2012-12-16T21:00:38Z","timestamp":1355691638000},"page":"1-5","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy of Eosin B as a New Antimalarial Drug in a Murine Model"],"prefix":"10.1155","volume":"2012","author":[{"given":"Zahra","family":"Zamani","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Pasteur Institute of Iran, Tehran 1316943551, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alireza Sadeghi","family":"Tafreshi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Payame Noor University, Tahran 193195, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hossein","family":"Nahrevanian","sequence":"additional","affiliation":[{"name":"Department of 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