{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:50:16Z","timestamp":1761630616349,"version":"3.37.3"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Rheumatology"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>The performance of the interferon gamma release assays (IGRAs) and tuberculin skin test (TST) was reviewed retrospectively in patients with psoriasis, inflammatory musculoskeletal diseases, or miscellaneous inflammatory conditions. The study was carried out over a 22-month period using 109 records of patients with psoriasis (), musculoskeletal disease (), or other inflammatory conditions (). Forty-four (48%) of 109 patients were on immunosuppressive therapy and 38\/109 (35%) on systemic glucocorticoid therapy. The agreement between the IGRAs was substantial () whilst that between the IGRAs and TST was low (). Logistic regression models revealed that IGRAs associated with risk factors for latent tuberculosis infection better than TST. TST was influenced by age, BCG vaccination, sex, and glucocorticoid therapy. We found that IGRAs performed equally well with low level of indeterminate results (1-2%). IGRAs were superior to TST because the latter was influenced by BCG-vaccination status and immunosuppressive therapy.<\/jats:p>","DOI":"10.1155\/2012\/381929","type":"journal-article","created":{"date-parts":[[2012,5,17]],"date-time":"2012-05-17T08:27:35Z","timestamp":1337243255000},"page":"1-8","source":"Crossref","is-referenced-by-count":16,"title":["Immunosuppression Adversely Affects TST but Not IGRAs in Patients with Psoriasis or Inflammatory Musculoskeletal Diseases"],"prefix":"10.1155","volume":"2012","author":[{"given":"Esko","family":"Tavast","sequence":"first","affiliation":[{"name":"Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, P.O. Box 21, 00014 Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamara","family":"Tuuminen","sequence":"additional","affiliation":[{"name":"Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, P.O. Box 21, 00014 Helsinki, Finland"},{"name":"Eastern Finland Laboratory Centre Joint Authority Enterprise (ISLAB), Mikkeli District Laboratory, Porrassalmenkatu 35-37, FI-50100 Mikkeli, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sari H.","family":"Pakkanen","sequence":"additional","affiliation":[{"name":"Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, P.O. Box 21, 00014 Helsinki, Finland"},{"name":"Division of Infectious Diseases, Department of Medicine, Helsinki University Central Hospital, P.O. Box 348, FI-00029 HUS, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari","family":"Eriksson","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Helsinki University Central Hospital, P.O. Box 348, FI-00029 HUS, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0004-1000","authenticated-orcid":true,"given":"Anu","family":"Kantele","sequence":"additional","affiliation":[{"name":"Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, P.O. Box 21, 00014 Helsinki, Finland"},{"name":"Division of Infectious Diseases, Department of Medicine, Helsinki University Central Hospital, P.O. Box 348, FI-00029 HUS, Helsinki, Finland"},{"name":"Institute of Clinical Medicine, University of Helsinki, P.O. Box 20, 00014 Helsingin Yliopisto, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asko","family":"J\u00e4rvinen","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Helsinki University Central Hospital, P.O. Box 348, FI-00029 HUS, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liana","family":"Pusa","sequence":"additional","affiliation":[{"name":"Department of Internal Diseases, L\u00e4nsi-Uusimaa Hospital, P.O. Box 1020, It\u00e4inen rantakatu 9, 10601 Tammisaari, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarja","family":"M\u00e4lk\u00f6nen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology, Helsinki University Central Hospital, P.O. Box 160, HUS 00029, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilkka","family":"Sepp\u00e4l\u00e4","sequence":"additional","affiliation":[{"name":"Division of Clinical Microbiology, Helsinki University Central Hospital, HUSLAB, P.O. 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