{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T22:27:46Z","timestamp":1757543266438,"version":"3.37.3"},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research","doi-asserted-by":"publisher","award":["SIP-0006","SIP-0007","MLP-0016"],"award-info":[{"award-number":["SIP-0006","SIP-0007","MLP-0016"]}],"id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research","doi-asserted-by":"publisher","award":["SIP-0006","SIP-0007","MLP-0016"],"award-info":[{"award-number":["SIP-0006","SIP-0007","MLP-0016"]}],"id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research","doi-asserted-by":"publisher","award":["SIP-0006","SIP-0007","MLP-0016"],"award-info":[{"award-number":["SIP-0006","SIP-0007","MLP-0016"]}],"id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>Hyaluronan (HA) plays a significant role in maintaining aqueous humor outflow in trabecular meshwork, the primary ocular tissue involved in glaucoma. We examined potential association of the single nucleotide polymorphisms (SNPs) of the HA synthesizing gene \u2013 hyaluronan synthase 2 (<jats:italic>HAS2<\/jats:italic>), hyaluronan binding protein 1 (<jats:italic>HABP1<\/jats:italic>) and HA catabolic gene hyaluronidase 3 (<jats:italic>HYAL3<\/jats:italic>) in the primary open angle glaucoma (POAG) patients in the Indian population. Thirteen tagged SNPs (6 for<jats:italic>HAS2<\/jats:italic>, 3 for<jats:italic>HABP1<\/jats:italic>and 4 for<jats:italic>HYAL3<\/jats:italic>) were genotyped in 116 high tension (HTG), 321 non-high tension glaucoma (NHTG) samples and 96 unrelated, age-matched, glaucoma-negative, control samples. Allelic and genotypic association were analyzed by PLINK v1.04; haplotypes were identified using PHASE v2.1 and gene-gene interaction was analyzed using multifactor dimensionality reduction (MDR) v2.0. An allelic association (rs6651224;<jats:italic>p<\/jats:italic>= 0.03; OR: 0.49; 95% CI: 0.25\u20130.94) was observed at the second intron (C&gt;G) of<jats:italic>HAS2<\/jats:italic>both for NHTG and HTG. rs1057308 revealed a genotypic association (<jats:italic>p<\/jats:italic>= 0.03) at the 5\u2019 UTR of<jats:italic>HAS2<\/jats:italic>with only HTG. TCT haplotype (rs1805429 \u2013 rs2472614 \u2013 rs8072363) in<jats:italic>HABP1<\/jats:italic>and TTAG and TTGA (rs2285044 \u2013 rs3774753 \u2013 rs1310073 \u2013 rs1076872) in<jats:italic>HYAL3<\/jats:italic>were found to be significantly high (<jats:italic>p<\/jats:italic>&lt; 0.05) both for HTG and NHTG compared to controls. Gene-gene interaction revealed<jats:italic>HABP1<\/jats:italic>predominantly interacts with<jats:italic>HAS2<\/jats:italic>in HTG while it associates with both<jats:italic>HYAL3<\/jats:italic>and<jats:italic>HAS2<\/jats:italic>in NHTG. This is the first genetic evidence, albeit from a smaller study, that the natural polymorphisms in the genes involved in hyaluronan metabolism are potentially involved in glaucomatous neurodegeneration.<\/jats:p>","DOI":"10.1155\/2012\/390539","type":"journal-article","created":{"date-parts":[[2013,6,13]],"date-time":"2013-06-13T05:39:17Z","timestamp":1371101957000},"page":"145-154","source":"Crossref","is-referenced-by-count":3,"title":["Genetic Association and Gene-gene interaction of<i>HAS2<\/i>,<i>HABP1<\/i>and<i>HYAL3<\/i>Implicate Hyaluronan Metabolic Genes in Glaucomatous Neurodegeneration"],"prefix":"10.1155","volume":"33","author":[{"given":"Kaustuv","family":"Basu","sequence":"first","affiliation":[{"name":"Biochemistry Laboratory, School of Environmental Sciences, Jawaharlal Nehru University, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhijit","family":"Sen","sequence":"additional","affiliation":[{"name":"Dristi Pradip, Jodhpur Park, Kolkata, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunal","family":"Ray","sequence":"additional","affiliation":[{"name":"Molecular and Human Genetics Division, CSIR-Indian Institute of Chemical Biology, Kolkata, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilora","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Biochemistry Laboratory, School of Environmental Sciences, Jawaharlal Nehru University, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kasturi","family":"Datta","sequence":"additional","affiliation":[{"name":"Biochemistry Laboratory, School of Environmental Sciences, Jawaharlal Nehru University, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arijit","family":"Mukhopadhyay","sequence":"additional","affiliation":[{"name":"Genomics and Molecular Medicine, CSIR-Institute of Genomics and Integrative Biology, Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","container-title":["Disease Markers"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2012\/390539.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2012\/390539.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,8,23]],"date-time":"2016-08-23T05:08:29Z","timestamp":1471928909000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/dm\/2012\/390539\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012]]}},"alternative-id":["390539"],"URL":"https:\/\/doi.org\/10.1155\/2012\/390539","relation":{},"ISSN":["0278-0240","1875-8630"],"issn-type":[{"type":"print","value":"0278-0240"},{"type":"electronic","value":"1875-8630"}],"subject":[],"published":{"date-parts":[[2012]]}}}