{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T12:34:08Z","timestamp":1789130048282,"version":"build-2803163510"},"reference-count":59,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Oncology"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. To compare the impact of prognostic factors of patients treated with definitive radio(chemo)therapy versus patients treated with surgery and postoperative radiotherapy for squamous cell carcinoma of the oro- and hypopharynx.<jats:italic>Patients and Methods<\/jats:italic>. 162 patients treated with definitive radiotherapy and 126 patients treated with postoperative radiotherapy were retrospectively analysed. The impact of the prognostic factors gender, age, total tumor volume (TTV), pre-radiotherapy hemoglobin level (Hb-level), tumor site, T- and N-classification, radiotherapy interruptions &gt;5 days, radiotherapy versus simultaneous radiochemotherapy, R-status and time interval between surgery and radiotherapy were investigated.<jats:italic>Results<\/jats:italic>. The median follow-up time for the censored patients treated with definitive radio(chemo)therapy was 28.5 months and for postoperative radiotherapy 36.5 months. On univariate analysis, the TTV, Hb-level, and simultaneous radiochemotherapy had a significant impact on the survival of patients treated with definitive radio(chemo)therapy. For patients treated with postoperative radiotherapy, only the TTV showed a statistical trend for the survival (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.13<\/mml:mn><\/mml:math>). On multivariate analysis, the TTV and simultaneous radiochemotherapy maintained their statistical significance for patients treated with definitive raditherapy, and the TTV, the statistical trend for patients treated with postoperative radiotherapy (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.19<\/mml:mn><\/mml:math>).<jats:italic>Conclusions<\/jats:italic>. The TTV was the predominant prognostic factor for both, patients treated with definitive or postoperative radiotherapy.<\/jats:p>","DOI":"10.1155\/2012\/391917","type":"journal-article","created":{"date-parts":[[2012,1,18]],"date-time":"2012-01-18T21:01:53Z","timestamp":1326920513000},"page":"1-10","source":"Crossref","is-referenced-by-count":4,"title":["Definitive Radiotherapy versus Postoperative Radiotherapy of Patients with Oro- and Hypopharyngeal Cancer: Impact of Prognostic Factors"],"prefix":"10.1155","volume":"2012","author":[{"given":"Volker","family":"Rudat","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, University of Heidelberg, Heidelberg 69120, Germany"},{"name":"Department of Radiation Oncology, Saad Specialist Hospital, Al-Khobar 31952, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salia","family":"Ahmet-Osman","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University of 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