{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T14:19:33Z","timestamp":1784297973198,"version":"3.55.0"},"reference-count":57,"publisher":"Wiley","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100006181","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado da Bahia","doi-asserted-by":"publisher","award":["482113\/2010-3"],"award-info":[{"award-number":["482113\/2010-3"]}],"id":[{"id":"10.13039\/501100006181","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["482113\/2010-3"],"award-info":[{"award-number":["482113\/2010-3"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Parasitology Research"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>Periportal fibrosis in schistosomiasis has been associated to the host immune response to parasite antigens. We evaluated the immune response in<jats:italic>S. mansoni<\/jats:italic>infected individuals with different degrees of periportal fibrosis. Cytokine and chemokines were measured in serum and in supernatants of PBMC cultures stimulated with the soluble adult worm (SWAP) or egg (SEA) antigens, using a sandwich ELISA. The levels of IL-5 in response to SEA were higher in individuals with moderate to severe fibrosis (310.9\u2009pg\/mL) compared to individuals without fibrosis (36.8\u2009pg\/mL;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.0418<\/mml:mn><\/mml:mrow><\/mml:math>). There was also a higher production of TNF-<jats:italic>\u03b1<\/jats:italic>in cultures stimulated with SWAP in patients with insipient fibrosis (1446\u2009pg\/mL) compared to those without fibrosis (756.1\u2009pg\/mL;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.0319<\/mml:mn><\/mml:mrow><\/mml:math>). The serum levels of IL-13 and MIP-1<jats:italic>\u03b1<\/jats:italic>were higher in subjects without fibrosis than in those with moderate to severe fibrosis. However a positive association between serum levels of IL-13, TNF-<jats:italic>\u03b1<\/jats:italic>, MIP-1<jats:italic>\u03b1<\/jats:italic>, and RANTES and<jats:italic>S. mansoni<\/jats:italic>parasite burden was found. From these data we conclude that IL-5 and TNF-<jats:italic>\u03b1<\/jats:italic>may participate in liver pathology in schistosomiasis. The positive association between IL-13, TNF-<jats:italic>\u03b1<\/jats:italic>, MIP-1<jats:italic>\u03b1<\/jats:italic>, and RANTES with parasite burden, however, might predict the development of liver pathology.<\/jats:p>","DOI":"10.1155\/2012\/394981","type":"journal-article","created":{"date-parts":[[2012,12,25]],"date-time":"2012-12-25T21:04:24Z","timestamp":1356469464000},"page":"1-10","source":"Crossref","is-referenced-by-count":12,"title":["Cytokine and Chemokine Profile in Individuals with Different Degrees of Periportal Fibrosis due to<i>Schistosoma mansoni<\/i>Infection"],"prefix":"10.1155","volume":"2012","author":[{"given":"Robson Da Paix\u00e3o","family":"De Souza","sequence":"first","affiliation":[{"name":"Servi\u00e7o de Imunologia, Complexo Hospitalar Universit\u00e1rio Professor Edgard Santos, Universidade Federal da Bahia, Rua Jo\u00e3o das Botas s\/n, Canela, 40.110-160 Salvador, BA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana 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Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Cec\u00edlia F.","family":"Almeida","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Imunologia, Complexo Hospitalar Universit\u00e1rio Professor Edgard Santos, Universidade Federal da Bahia, Rua Jo\u00e3o das Botas s\/n, Canela, 40.110-160 Salvador, BA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Riccio","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Imunologia, Complexo Hospitalar Universit\u00e1rio Professor Edgard Santos, Universidade Federal da Bahia, Rua Jo\u00e3o das Botas s\/n, Canela, 40.110-160 Salvador, BA, Brazil"},{"name":"Instituto Nacional de Ci\u00eancia e Tecnologia em Doen\u00e7as Tropicais (INCT-DT-CNPQ\/MCT), Rua Jo\u00e3o das Botas s\/n, Canela, 40.110-160 Salvador, BA, Brazil"},{"name":"Departamento de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas, Faculdade de Farm\u00e1cia, UFBA, Avenida Adhemar 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