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There is almost no useful animal model that is globally recognized and routinely used, however, several unique animal models manifested the characteristic clinical and pathological features of human PBC within the last 5 years. Herein, we compare the pathological features of previously reported and newly introduced novel animal models of PBC. Knowledge and understanding of the strengths and the limitations of each animal model have led to the development of promising therapies and novel tools to characterize these clinical conditions. Moreover, suitability of the model for the intended purpose should be confirmed by further research and analysis.<\/jats:p>","DOI":"10.1155\/2012\/403954","type":"journal-article","created":{"date-parts":[[2011,7,13]],"date-time":"2011-07-13T14:31:57Z","timestamp":1310567517000},"page":"1-7","source":"Crossref","is-referenced-by-count":12,"title":["Pathological Features of New Animal Models for Primary Biliary Cirrhosis"],"prefix":"10.1155","volume":"2012","author":[{"given":"Koichi","family":"Tsuneyama","sequence":"first","affiliation":[{"name":"Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Science, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Moritoki","sequence":"additional","affiliation":[{"name":"Department of Infection, Allergy, Clinical Immunology and Laboratory Medicine, Graduate School of Medicine, Akita University, Hondo, Akita 010-8543, 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