{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T22:25:26Z","timestamp":1749853526508},"reference-count":51,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"National Clinical Specialties of China","award":["2100-305"],"award-info":[{"award-number":["2100-305"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology Research and Practice"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. Antimicrobial resistance has decreased eradication rates for<jats:italic>Helicobacter pylori<\/jats:italic>infection worldwide. To observe the effect of eradicating<jats:italic>Helicobacter pylori (H. pylori)<\/jats:italic>and the treatment of duodenal ulcer by 2 kinds of modified sequential therapy through comparing with that of 10-day standard triple therapy.<jats:italic>Methods<\/jats:italic>. A total of 210 patients who were confirmed in duodenal ulcer active or heal period by gastroscopy and<jats:italic>H. pylori<\/jats:italic>positive confirmed by rapid urease test, serum anti-<jats:italic>H. pylori<\/jats:italic>antibody (ELASE), or histological examination enrolled in the study. All the patients were randomly divided into three groups: group A (70 cases) and group B (70 cases) were provided 10-day modified sequential therapy; group C (70 cases) was provided 10-day standard triple therapy. Patients of group A received 20\u2009mg of Esomeprazole, 500\u2009mg of Clarithromycin for the first 5 days, followed by 20\u2009mg of Esomeprazole, 500\u2009mg of Clarithromycin, and 1000\u2009mg of Amoxicillin for the remaining 5 days. Group B received 20\u2009mg of Esomeprazole, 1000\u2009mg of Amoxicillin for the first 5 days, followed by 20\u2009mg of Esomeprazole, 500\u2009mg of Clarithromycin, and 1000\u2009mg of Amoxicillin for the remaining 5 days. Group C received 20\u2009mg of Esomeprazole, 500\u2009mg of Clarithromycin, and 1000\u2009mg of Amoxicillin for standard 10-day therapy. All drugs were given twice daily.<jats:italic>H. pylori<\/jats:italic>eradication rate was checked four to eight weeks after taking the medicine by using a<jats:sup>13<\/jats:sup>C urea breath test. In the first, second, third, seventh, twenty-first, thirty-fifth days respectively, the symptoms of patients such as epigastric gnawing, burning pain, and acidity were evaluated simultaneously.<jats:italic>Results<\/jats:italic>. Overall, 210 patients accomplished all therapy schemes, 9 case patients were excluded. The examination result indicated that the<jats:italic>H. pylori<\/jats:italic>eradication rate of each group was as follows: group A 92.5% (62\/67), group B 86.8% (59\/68), and group C 78.8% (52\/66). The<jats:italic>H. pylori<\/jats:italic>eradication rate of group A was slightly higher than group B (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>) and both of them were obviously higher than group C (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>). Modified sequential therapy was significantly more effective in patients with clarithromycin-resistant strains (80%\/67% versus 31%;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.02<\/mml:mn><\/mml:math>). Symptoms improvement: all the three groups could improve the symptoms such as epigastric gnawing, burning pain, and acidity since the first day. There was no significant difference in total score descending of symptoms between each group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>P<\/mml:mi><mml:mo>&gt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>).<jats:italic>Conclusions<\/jats:italic>. All the three therapy schemes could alleviate symptoms of duodenal ulcer patients in China efficiently. But as far as eradicating<jats:italic>H. pylori<\/jats:italic>is concerned, the modified sequential therapy was better than standard triple therapy, especially the therapy scheme used in group A.<\/jats:p>","DOI":"10.1155\/2012\/405425","type":"journal-article","created":{"date-parts":[[2012,4,9]],"date-time":"2012-04-09T21:01:39Z","timestamp":1334005299000},"page":"1-8","source":"Crossref","is-referenced-by-count":10,"title":["Modified Sequential Therapy Regimen versus Conventional Triple Therapy for<i>Helicobacter pylori<\/i>Eradication in Duodenal Ulcer Patients in China: A Multicenter Clinical Comparative Study"],"prefix":"10.1155","volume":"2012","author":[{"given":"Ying-Qun","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University, Shanghai 200072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Xu","sequence":"additional","affiliation":[{"name":"Department 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