{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:48:36Z","timestamp":1787017716161,"version":"build-2736575974"},"reference-count":134,"publisher":"Wiley","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Oncology"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>\n                    Adrenocortical carcinoma (ACC) is a very rare endocrine tumour, with variable prognosis, depending on tumour stage and time of diagnosis. The overall survival is five years from detection. Radical surgery is considered the therapy of choice in the first stages of ACC. However postoperative disease-free survival at 5 years is only around 30% and recurrence rates are frequent.\n                    <jats:italic>o,p\u2019<\/jats:italic>\n                    DDD (\n                    <jats:italic>ortho-, para\u2019-,<\/jats:italic>\n                    dichloro-, diphenyl-, dichloroethane, or mitotane), an adrenolytic drug with significant toxicity and unpredictable therapeutic response, is used in the treatment of ACC. Unfortunately, treatment for this aggressive cancer is still ineffective. Over the past years, the growing interest in ACC has contributed to the development of therapeutic strategies in order to contrast the neoplastic spread. In this paper we discuss the most promising therapies which can be used in this endocrine neoplasia.\n                  <\/jats:p>","DOI":"10.1155\/2012\/408131","type":"journal-article","created":{"date-parts":[[2012,8,14]],"date-time":"2012-08-14T17:01:03Z","timestamp":1344963663000},"page":"1-13","source":"Crossref","is-referenced-by-count":10,"title":["Current and Emerging Therapeutic Options in Adrenocortical Cancer Treatment"],"prefix":"10.1155","volume":"2012","author":[{"given":"Antonio","family":"Stigliano","sequence":"first","affiliation":[{"name":"Endocrinology, Department of Clinical and Molecular Medicine, Sant'Andrea Hospital, Faculty of Medicine and Psychology, \u201cSapienza\u201d University of Rome, Via di Grottarossa, 1035, 00189 Rome, Italy"},{"name":"Research Center, San Pietro Hospital Fatebenefratelli, Via Cassia 600, 00189\/Rome, 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