{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T02:23:36Z","timestamp":1791426216273,"version":"4.3.3"},"reference-count":61,"publisher":"Wiley","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Endocrinology"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Primary hyperparathyroidism (PHPT) is associated with high cardiovascular morbidity, and the role of calcium and parathyroid hormone is still controversial.<jats:italic>Objective<\/jats:italic>. To evaluate the prevalence and outcomes of metabolic syndrome, hypertension, and some cardiovascular alterations in asymptomatic PHPT, and specific changes after successful parathyroidectomy.<jats:italic>Material and Methods<\/jats:italic>. We examined 30 newly diagnosed PHPT patients (8 males, 22 females; mean age \u2009yrs), 30 patients with essential hypertension (EH) (9 males, 21 females; mean age ), and 30 normal subjects (NS) (9 males, 21 females: mean age ). All groups underwent evaluation with ambulatory monitoring blood pressure, echocardiography, and color-Doppler artery ultrasonography and were successively revaluated after one year from parathyroidectomy.<jats:italic>Results<\/jats:italic>. PHPT patients presented a higher prevalence of metabolic syndrome (38%) with respect to EH (28%). Prevalence of hypertension in PHPT was 81%, and 57% presented altered circadian rhythm of blood pressure, with respect to EH (35%) and NS (15%). PHPT showed an important myocardial and vascular remodelling. During follow-up in PHPT patients, we found significant reduction of prevalence of metabolic syndrome, blood pressure, and \u201cnon-dipping phenomenon.\u201d<jats:italic>Conclusions<\/jats:italic>. Cardiovascular and metabolic alterations should be considered as added parameters in evaluation of patients with asymptomatic PHPT.<\/jats:p>","DOI":"10.1155\/2012\/408295","type":"journal-article","created":{"date-parts":[[2012,6,7]],"date-time":"2012-06-07T17:01:23Z","timestamp":1339088483000},"page":"1-10","source":"Crossref","is-referenced-by-count":63,"title":["Arterial Hypertension, Metabolic Syndrome and Subclinical Cardiovascular Organ Damage in Patients with Asymptomatic Primary Hyperparathyroidism before and after Parathyroidectomy: Preliminary Results"],"prefix":"10.1155","volume":"2012","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4463-4956","authenticated-orcid":true,"given":"Petramala","family":"Luigi","sequence":"first","affiliation":[{"name":"Secondary Hypertension Unit, Department of Internal Medicine and Medical Specialties, University of Rome \u201cSapienza\u201d, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8913-2549","authenticated-orcid":true,"given":"Formicuccia Maria","family":"Chiara","sequence":"additional","affiliation":[{"name":"Secondary Hypertension Unit, Department of Internal Medicine and Medical Specialties, University of Rome \u201cSapienza\u201d, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zinnamosca","family":"Laura","sequence":"additional","affiliation":[{"name":"Secondary Hypertension Unit, Department of Internal Medicine and Medical Specialties, University of Rome \u201cSapienza\u201d, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marinelli","family":"Cristiano","sequence":"additional","affiliation":[{"name":"Secondary Hypertension Unit, Department of Internal Medicine and Medical Specialties, University of Rome \u201cSapienza\u201d, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cilenti","family":"Giuseppina","sequence":"additional","affiliation":[{"name":"Secondary Hypertension Unit, Department of Internal Medicine and Medical Specialties, University of Rome \u201cSapienza\u201d, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colangelo","family":"Luciano","sequence":"additional","affiliation":[{"name":"Secondary Hypertension Unit, Department of Internal Medicine and Medical Specialties, University of Rome \u201cSapienza\u201d, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panzironi","family":"Giuseppe","sequence":"additional","affiliation":[{"name":"Secondary Hypertension Unit, Department of Internal Medicine and Medical Specialties, University of Rome \u201cSapienza\u201d, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cerci","family":"Sabrina","sequence":"additional","affiliation":[{"name":"Hospital \u201cSan Sebastiano\u201d of Frascati, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sciomer","family":"Susanna","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular, Respiratory and Morphological Sciences, University of Rome \u201cSapienza\u201d, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciardi","family":"Antonio","sequence":"additional","affiliation":[{"name":"Department of Surgery \u201cP. 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