{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:25:40Z","timestamp":1759530340912},"reference-count":53,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Show Chwan Memorial Hospital, Changhua, Taiwan","award":["RD96007","RD97022"],"award-info":[{"award-number":["RD96007","RD97022"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>Alzheimer's disease (AD) is an irreversible neurodegenerative disorder characterized by amyloid accumulation, neuronal death, and cognitive impairments. Yi-Chi-Tsung-Ming-Tang (YCTMT) is a traditional Chinese medicine and has never been used to enhance cognitive function and treat neurodegenerative disorders such as senile dementia. Whether YCTMT has a beneficial role in improving learning and memory in AD patients remains unclear. The present study showed that oral administration of YCTMT ameliorated amyloid-<jats:italic>\u03b2<\/jats:italic>- (A<jats:italic>\u03b2<\/jats:italic><jats:sub>1\u221240<\/jats:sub>) injection-induced learning and memory impairments in rats, examined using passive avoidance and Morris water-maze tests. Immunostaining and Western Blot results showed that continuous A<jats:italic>\u03b2<\/jats:italic><jats:sub>1\u221240<\/jats:sub>infusion caused amyloid accumulation and decreased acetylcholine level in hippocampus. Oral administration of medium and high dose of YCTMT 7 days after the A<jats:italic>\u03b2<\/jats:italic><jats:sub>1\u221240<\/jats:sub>infusion decreased amyloid accumulation area and reversed acetylcholine decline in the A<jats:italic>\u03b2<\/jats:italic><jats:sub>1\u221240<\/jats:sub>-injected hippocampus, suggesting that YCTMT might inhibit A<jats:italic>\u03b2<\/jats:italic>plague accumulation and rescue reduced acetylcholine expression. This study has provided evidence on the beneficial role of YCTMT in ameliorating amyloid-induced AD-like symptom, indicating that YCTMT may offer an alternative strategy for treating AD.<\/jats:p>","DOI":"10.1155\/2012\/414536","type":"journal-article","created":{"date-parts":[[2012,6,13]],"date-time":"2012-06-13T21:01:10Z","timestamp":1339621270000},"page":"1-10","source":"Crossref","is-referenced-by-count":2,"title":["Therapeutic Effect of Yi-Chi-Tsung-Ming-Tang on Amyloid<i>\u03b2<\/i><sub>1\u221240<\/sub>-Induced Alzheimer's Disease-Like Phenotype via an Increase of Acetylcholine and Decrease of Amyloid<i>\u03b2<\/i>"],"prefix":"10.1155","volume":"2012","author":[{"given":"Chung-Hsin","family":"Yeh","sequence":"first","affiliation":[{"name":"Department of Neurology, Show Chwan Memorial Hospital, Changhua, Taiwan"},{"name":"Graduate Institute of Life Sciences, National Chung Hsing University, Taichung 40001, Taiwan"},{"name":"Department of Nursing, College of Medicine & Nursing, 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