{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T21:41:22Z","timestamp":1649022082636},"reference-count":21,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Hematology"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>Histiocytic sarcoma (HS) is a neoplasm derived from histiocytes. Its diagnosis was not clear until its immunohistochemistry profile was correctly established. Not much is known about its genetic properties. We report a case of a 48-year-old male patient whose bone marrow was almost completely occupied by monomorphic medium size neoplastic cellularity. Its immunohistochemical profile was CD68<jats:sup>+<\/jats:sup>, CD4<jats:sup>+<\/jats:sup>, CD45<jats:sup>+<\/jats:sup>with negativity of other dendritic cells, and other lineage markers. Cytogenetic study showed 4 related clones: one with trisomy 8 and extra material on the short arms of chromosome 4; a second line with tetrasomy of chromosome 8, add(4)(p16); the third clone had the same alterations as the previous and deletion of chromosome 3 at q11; the fourth line had tetrasomy 8 and translocation t(3;5)(q25;q35). To our knowledge this is the first HS case showing chromosome 8 trisomy and tetrasomy and the other described alterations.<\/jats:p>","DOI":"10.1155\/2012\/428279","type":"journal-article","created":{"date-parts":[[2012,6,4]],"date-time":"2012-06-04T15:30:57Z","timestamp":1338823857000},"page":"1-4","source":"Crossref","is-referenced-by-count":1,"title":["Cytogenetics Findings in a Histiocytic Sarcoma Case"],"prefix":"10.1155","volume":"2012","author":[{"given":"J. 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