{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:51:26Z","timestamp":1791280286185,"version":"4.1.0"},"reference-count":93,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Advances in Urology"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>Fibroblast growth factors (FGFs) orchestrate a variety of cellular functions by binding to their transmembrane tyrosine-kinase receptors (FGFRs) and activating downstream signalling pathways, including RAS\/MAPK, PLC<jats:italic>\u03b3<\/jats:italic>1, PI3K, and STATs. In the last ten years, it has become clear that FGF signalling is altered in a high proportion of bladder tumours. Activating mutations and\/or overexpression of<jats:italic>FGFR3<\/jats:italic>are common in urothelial tumours with low malignant potential and low-stage and -grade urothelial carcinomas (UCs) and are associated with a lower risk of progression and better survival in some subgroups.<jats:italic>FGFR1<\/jats:italic>is not mutated in UC, but overexpression is frequent in all grades and stages and recent data indicate a role in urothelial epithelial-mesenchymal transition.<jats:italic>In vitro<\/jats:italic>and<jats:italic>in vivo<\/jats:italic>studies have shown that FGFR inhibition has cytotoxic and\/or cytostatic effects in FGFR-dependent bladder cancer cells and FGFR-targeted agents are currently being investigated in clinical studies for the treatment of UC. Urine-based tests detecting common<jats:italic>FGFR3<\/jats:italic>mutations are also under development for surveillance of low-grade and -stage tumours and for general population screening. Overall, FGFRs hold promise as therapeutic targets, diagnostic and prognostic markers, and screening tools for early detection and clinical management of UC.<\/jats:p>","DOI":"10.1155\/2012\/429213","type":"journal-article","created":{"date-parts":[[2012,7,31]],"date-time":"2012-07-31T21:01:09Z","timestamp":1343768469000},"page":"1-10","source":"Crossref","is-referenced-by-count":91,"title":["A Decade of FGF Receptor Research in Bladder Cancer: Past, Present, and Future Challenges"],"prefix":"10.1155","volume":"2012","author":[{"given":"Erica","family":"di Martino","sequence":"first","affiliation":[{"name":"Section of Experimental Oncology, Leeds Institute of Molecular Medicine, St James\u2019s University Hospital, Leeds LS9 7TF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren C.","family":"Tomlinson","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret A.","family":"Knowles","sequence":"additional","affiliation":[{"name":"Section of Experimental Oncology, Leeds Institute of Molecular Medicine, St James\u2019s University Hospital, Leeds LS9 7TF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20073"},{"key":"2","year":"2004"},{"key":"3","year":"2010"},{"key":"4","year":"1999"},{"issue":"6","key":"5","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1016\/j.juro.2011.07.076","volume":"186","year":"2011","journal-title":"The Journal of Urology"},{"issue":"18","key":"6","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1007\/BF03262330","volume":"21","year":"2003","journal-title":"Pharmacoeconomics"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2005.05249.x"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-5394.2002.106011.x"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2005.12.031"},{"issue":"2","key":"10","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/j.1464-410X.1994.tb07487.x","volume":"73","year":"1994","journal-title":"British Journal of Urology"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410X.2000.00356.x"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1210\/er.2003-0040"},{"issue":"3","key":"13","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1677\/erc.0.0070165","volume":"7","year":"2000","journal-title":"Endocrine-Related Cancer"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2792"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0307287101"},{"key":"16","doi-asserted-by":"crossref","first-page":"D165","DOI":"10.2741\/A419","volume":"4","year":"1999","journal-title":"Frontiers in Bioscience"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.25.15292"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M601252200"},{"issue":"15","key":"19","doi-asserted-by":"crossref","first-page":"11620","DOI":"10.1016\/S0021-9258(19)78170-8","volume":"269","year":"1994","journal-title":"The Journal of Biological Chemistry"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.17.10231"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1006\/mcbr.2000.0199"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1006\/mcbr.2001.0306"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(01)00518-2"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-010-0576-3"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1038\/12615"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204110"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1002\/path.1202"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.05.1771"},{"issue":"6","key":"29","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1016\/S0002-9440(10)64665-2","volume":"158","year":"2001","journal-title":"American The Journal of Pathology"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2007.12.026"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2008.06.013"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1002\/path.2207"},{"issue":"5","key":"33","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1359\/jbmr.2002.17.5.860","volume":"17","year":"2002","journal-title":"Journal of Bone and Mineral Research"},{"issue":"1","key":"34","first-page":"71","volume":"9","year":"1998","journal-title":"Cell Growth and Differentiation"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2011.04.007"},{"issue":"8","key":"36","doi-asserted-by":"crossref","first-page":"4081","DOI":"10.1128\/MCB.16.8.4081","volume":"16","year":"1996","journal-title":"Molecular and Cellular Biology"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2006.01.058"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-1718"},{"issue":"10","key":"46","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1002\/1097-0142(20011115)92:10<2555::AID-CNCR1607>3.0.CO;2-M","volume":"92","year":"2001","journal-title":"Cancer"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2010.05.003"},{"issue":"4","key":"79","first-page":"1265","volume":"61","year":"2001","journal-title":"Cancer Research"},{"key":"92","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5200883"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700422"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1038\/ng0797-260"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204651"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204543"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgh275"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1002\/mc.20573"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2009.280"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21958"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2005.03.001"},{"issue":"5","key":"48","first-page":"967","volume":"12","year":"2004","journal-title":"Oncology Reports"},{"issue":"2","key":"49","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1158\/1078-0432.459.11.2","volume":"11","year":"2005","journal-title":"Clinical Cancer Research"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21743"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-0744"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1007\/BF00299719"},{"issue":"4","key":"54","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/S0022-5347(17)35705-1","volume":"150","year":"1993","journal-title":"Journal of Urology"},{"issue":"5","key":"56","first-page":"1063","volume":"5","year":"1999","journal-title":"Clinical Cancer Research"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910610205"},{"issue":"2","key":"58","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1073\/pnas.91.2.484","volume":"91","year":"1994","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-3746"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402556"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-1164"},{"issue":"23","key":"62","first-page":"8256","volume":"63","year":"2003","journal-title":"Cancer Research"},{"issue":"19","key":"63","first-page":"6237","volume":"63","year":"2003","journal-title":"Cancer Research"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200107119"},{"key":"65","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2007.11.004"},{"key":"66","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-2816"},{"key":"67","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.100354"},{"issue":"3","key":"68","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/sj.onc.1200830","volume":"14","year":"1997","journal-title":"Oncogene"},{"issue":"51","key":"69","doi-asserted-by":"crossref","first-page":"7234","DOI":"10.1038\/sj.onc.1203186","volume":"18","year":"1999","journal-title":"Oncogene"},{"key":"70","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgi290"},{"key":"71","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210399"},{"key":"72","doi-asserted-by":"publisher","DOI":"10.1172\/JCI38017"},{"key":"73","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-0282"},{"key":"93","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0038972"},{"key":"74","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-1045"},{"key":"75","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.03.141"},{"key":"76","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0013821"},{"key":"77","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2009.12.002"},{"key":"78","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25651"},{"key":"80","doi-asserted-by":"publisher","DOI":"10.1002\/path.2507"},{"issue":"1","key":"81","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.juro.2011.09.008","volume":"187","year":"2012","journal-title":"The Journal of Urology"},{"key":"82","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2010.05.043"},{"issue":"4","key":"83","first-page":"498","volume":"1","year":"2011","journal-title":"American Journal of Cancer Research"},{"key":"84","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.20.5896"},{"key":"85","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-1466"},{"key":"86","doi-asserted-by":"publisher","DOI":"10.1126\/science.276.5314.955"},{"key":"87","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.109.162768"},{"key":"88","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6606016"},{"key":"89","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2011.01.012"},{"key":"90","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(04)01467-6"},{"key":"91","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-07-0394"}],"container-title":["Advances in Urology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/au\/2012\/429213.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/au\/2012\/429213.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/au\/2012\/429213.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,25]],"date-time":"2023-06-25T01:13:53Z","timestamp":1687655633000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/au\/2012\/429213\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":93,"alternative-id":["429213","429213"],"URL":"https:\/\/doi.org\/10.1155\/2012\/429213","relation":{},"ISSN":["1687-6369","1687-6377"],"issn-type":[{"value":"1687-6369","type":"print"},{"value":"1687-6377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}